NKRF (NFKB repressing factor)

2007-04-01  

Identity

HGNC
NKRF
LOCATION
Xq24
LOCUSID
55922
ALIAS
ITBA4,NRF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55922
MIM: 300440
HGNC: 19374
Ensembl: ENSG00000186416

Variants:

dbSNP: 55922
ClinVar: 55922
TCGA: ENSG00000186416
COSMIC: NKRF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186416ENST00000304449O15226
ENSG00000186416ENST00000304449A3F769
ENSG00000186416ENST00000371527O15226
ENSG00000186416ENST00000371527A3F769
ENSG00000186416ENST00000542113O15226

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
252774102015MicroRNA 29 targets nuclear factor-κB-repressing factor and Claudin 1 to increase intestinal permeability.40
123817932002Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene.33
281156242017The G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.18
152263702004Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF.17
171865502007Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells.15
224417352012Reduced nuclear factor-κB repressing factor: a link toward systemic inflammation in COPD.11
195424522009Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor.8
251351112014NF-κB repressing factor downregulates basal expression and mycobacterium tuberculosis induced IP-10 and IL-8 synthesis via interference with NF-κB in monocytes.8
213000692011JKTBP1 is involved in stabilization and IRES-dependent translation of NRF mRNAs by binding to 5' and 3' untranslated regions.7
280963322017Human NF-κB repressing factor acts as a stress-regulated switch for ribosomal RNA processing and nucleolar homeostasis surveillance.7

Citation

Dessen P

NKRF (NFKB repressing factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47066/nkrf