NKX6-1 (NK6 homeobox 1)

2003-05-01  

Identity

HGNC
LOCATION
4q21.23
LOCUSID
ALIAS
NKX6.1,NKX6A

Other Information

Locus ID:

NCBI: 4825
MIM: 602563
HGNC: 7839
Ensembl: ENSG00000163623

Variants:

dbSNP: 4825
ClinVar: 4825
TCGA: ENSG00000163623
COSMIC: NKX6-1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163623ENST00000295886P78426
ENSG00000163623ENST00000515820F8VWZ9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Maturity onset diabetes of the youngKEGGko04950
Maturity onset diabetes of the youngKEGGhsa04950
Developmental BiologyREACTOMER-HSA-1266738
Regulation of beta-cell developmentREACTOMER-HSA-186712
Regulation of gene expression in early pancreatic precursor cellsREACTOMER-HSA-210747
Regulation of gene expression in beta cellsREACTOMER-HSA-210745

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437

References

Pubmed IDYearTitleCitations
238636252013Inactivation of specific β cell transcription factors in type 2 diabetes.162
238977602013Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.71
183470542008Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.54
244075762014High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma.25
211085352010NKX6.1 promotes PDX-1-induced liver to pancreatic β-cells reprogramming.23
288357092017Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.20
150567332004The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.19
168737042006Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.19
279982942016Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors.8
262570592016NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial-mesenchymal transition.5

Citation

Dessen P

NKX6-1 (NK6 homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41542/nkx6-1