Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NKX6-2 (NK6 homeobox 2)

Identity

Alias_namesNK6 transcription factor related, locus 2 (Drosophila)
Alias_symbol (synonym)NKX6B
GTX
NKX6.1
Other aliasNKX6.2
SPAX8
HGNC (Hugo) NKX6-2
LocusID (NCBI) 84504
Atlas_Id 70860
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 132784816 and ends at 132786033 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NKX6-2   19321
Cards
Entrez_Gene (NCBI)NKX6-2  84504  NK6 homeobox 2
AliasesGTX; NKX6.2; NKX6B; SPAX8
GeneCards (Weizmann)NKX6-2
Ensembl hg19 (Hinxton)ENSG00000148826 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148826 [Gene_View]  ENSG00000148826 [Sequence]  chr10:132784816-132786033 [Contig_View]  NKX6-2 [Vega]
ICGC DataPortalENSG00000148826
TCGA cBioPortalNKX6-2
AceView (NCBI)NKX6-2
Genatlas (Paris)NKX6-2
WikiGenes84504
SOURCE (Princeton)NKX6-2
Genetics Home Reference (NIH)NKX6-2
Genomic and cartography
GoldenPath hg38 (UCSC)NKX6-2  -     chr10:132784816-132786033 -  10q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKX6-2  -     10q26.3   [Description]    (hg19-Feb_2009)
GoldenPathNKX6-2 - 10q26.3 [CytoView hg19]  NKX6-2 - 10q26.3 [CytoView hg38]
ImmunoBaseENSG00000148826
Mapping of homologs : NCBINKX6-2 [Mapview hg19]  NKX6-2 [Mapview hg38]
OMIM605955   617560   
Gene and transcription
Genbank (Entrez)BC101635 BC104823 BF509028
RefSeq transcript (Entrez)NM_177400
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NKX6-2
Cluster EST : UnigeneHs.134013 [ NCBI ]
CGAP (NCI)Hs.134013
Alternative Splicing GalleryENSG00000148826
Gene ExpressionNKX6-2 [ NCBI-GEO ]   NKX6-2 [ EBI - ARRAY_EXPRESS ]   NKX6-2 [ SEEK ]   NKX6-2 [ MEM ]
Gene Expression Viewer (FireBrowse)NKX6-2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84504
GTEX Portal (Tissue expression)NKX6-2
Human Protein AtlasENSG00000148826-NKX6-2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C056   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C056  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C056
Splice isoforms : SwissVarQ9C056
PhosPhoSitePlusQ9C056
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    HTH_motif   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)NKX6-2
DMDM Disease mutations84504
Blocks (Seattle)NKX6-2
SuperfamilyQ9C056
Human Protein Atlas [tissue]ENSG00000148826-NKX6-2 [tissue]
Peptide AtlasQ9C056
HPRD09336
IPIIPI00028161   
Protein Interaction databases
DIP (DOE-UCLA)Q9C056
IntAct (EBI)Q9C056
FunCoupENSG00000148826
BioGRIDNKX6-2
STRING (EMBL)NKX6-2
ZODIACNKX6-2
Ontologies - Pathways
QuickGOQ9C056
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  nucleus  nucleus  regulation of transcription, DNA-templated  negative regulation of cell fate commitment  positive regulation of cell fate commitment  regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification  regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification  central nervous system myelination  cell differentiation  endocrine pancreas development  regulation of myelination  sequence-specific DNA binding  negative regulation of glial cell differentiation  positive regulation of glial cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  neuromuscular process controlling balance  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  nucleus  nucleus  regulation of transcription, DNA-templated  negative regulation of cell fate commitment  positive regulation of cell fate commitment  regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification  regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification  central nervous system myelination  cell differentiation  endocrine pancreas development  regulation of myelination  sequence-specific DNA binding  negative regulation of glial cell differentiation  positive regulation of glial cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  neuromuscular process controlling balance  
NDEx NetworkNKX6-2
Atlas of Cancer Signalling NetworkNKX6-2
Wikipedia pathwaysNKX6-2
Orthology - Evolution
OrthoDB84504
GeneTree (enSembl)ENSG00000148826
Phylogenetic Trees/Animal Genes : TreeFamNKX6-2
HOGENOMQ9C056
Homologs : HomoloGeneNKX6-2
Homology/Alignments : Family Browser (UCSC)NKX6-2
Gene fusions - Rearrangements
Fusion : QuiverNKX6-2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKX6-2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKX6-2
dbVarNKX6-2
ClinVarNKX6-2
1000_GenomesNKX6-2 
Exome Variant ServerNKX6-2
ExAC (Exome Aggregation Consortium)ENSG00000148826
GNOMAD BrowserENSG00000148826
Varsome BrowserNKX6-2
Genetic variants : HAPMAP84504
Genomic Variants (DGV)NKX6-2 [DGVbeta]
DECIPHERNKX6-2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKX6-2 
Mutations
ICGC Data PortalNKX6-2 
TCGA Data PortalNKX6-2 
Broad Tumor PortalNKX6-2
OASIS PortalNKX6-2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKX6-2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNKX6-2
Mutations and Diseases : HGMDNKX6-2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NKX6-2
DgiDB (Drug Gene Interaction Database)NKX6-2
DoCM (Curated mutations)NKX6-2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NKX6-2 (select a term)
intoGenNKX6-2
Cancer3DNKX6-2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605955    617560   
Orphanet
DisGeNETNKX6-2
MedgenNKX6-2
Genetic Testing Registry NKX6-2
NextProtQ9C056 [Medical]
TSGene84504
GENETestsNKX6-2
Target ValidationNKX6-2
Huge Navigator NKX6-2 [HugePedia]
snp3D : Map Gene to Disease84504
BioCentury BCIQNKX6-2
ClinGenNKX6-2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84504
Chemical/Pharm GKB GenePA134896334
Clinical trialNKX6-2
Miscellaneous
canSAR (ICR)NKX6-2 (select the gene name)
DataMed IndexNKX6-2
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNKX6-2
EVEXNKX6-2
GoPubMedNKX6-2
iHOPNKX6-2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Sep 3 15:57:50 CEST 2019

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