NLGN1 (neuroligin 1)

2003-05-01  

Identity

HGNC
LOCATION
3q26.31
LOCUSID
ALIAS
NL1
FUSION GENES

Other Information

Locus ID:

NCBI: 22871
MIM: 600568
HGNC: 14291
Ensembl: ENSG00000169760

Variants:

dbSNP: 22871
ClinVar: 22871
TCGA: ENSG00000169760
COSMIC: NLGN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169760ENST00000361589Q8N2Q7
ENSG00000169760ENST00000401917J3KQ19
ENSG00000169760ENST00000413821A0A1D5RMP7
ENSG00000169760ENST00000415045C9J4D3
ENSG00000169760ENST00000423427C9JWG7
ENSG00000169760ENST00000457714Q8N2Q7

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197363512009Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.151
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
205161562010Genome-wide association study of major recurrent depression in the U.K. population.87
157978752005Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.74
197304112009Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
160777342005Analysis of four neuroligin genes as candidates for autism.48
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
145229922003Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta.44
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34

Citation

Dessen P

NLGN1 (neuroligin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41543/nlgn1