NLGN3 (neuroligin 3)

2016-05-01  

Identity

HGNC
NLGN3
LOCATION
Xq13.1
LOCUSID
54413
ALIAS
HNL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54413
MIM: 300336
HGNC: 14289
Ensembl: ENSG00000196338

Variants:

dbSNP: 54413
ClinVar: 54413
TCGA: ENSG00000196338
COSMIC: NLGN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196338ENST00000358741Q9NZ94
ENSG00000196338ENST00000358741X5DNV3
ENSG00000196338ENST00000374051Q9NZ94
ENSG00000196338ENST00000374051X5D2P6
ENSG00000196338ENST00000395855E7EVK0
ENSG00000196338ENST00000536169Q9NZ94
ENSG00000196338ENST00000536169X5D7L6
ENSG00000196338ENST00000612180A0A087WW27

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126690652003Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.572
259131922015Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.120
156224152005Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients.110
166483742006Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism.63
289599752017Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.51
160777342005Analysis of four neuroligin genes as candidates for autism.48
153897662005NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population.42
152740462004Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands.32
165089392006Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection.32
186286832008Analysis of the neuroligin 4Y gene in patients with autism.26

Citation

Dessen P

NLGN3 (neuroligin 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55751/nlgn3