NLGN4X (neuroligin 4 X-linked)

2016-10-01 Affiliation

Identity

HGNC

NLGN4X

LOCATION

Xp22.32

LOCUSID

57502

ALIAS

ASPGX2,AUTSX2,HLNX,HNL4X,NLGN4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57502
MIM: 300427
HGNC: 14287
Ensembl: ENSG00000146938

Variants:

dbSNP: 57502
ClinVar: 57502
TCGA: ENSG00000146938
COSMIC: NLGN4X

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000146938	ENST00000275857	Q8N0W4
ENSG00000146938	ENST00000275857	A0A024RBV0
ENSG00000146938	ENST00000381092	Q8N0W4
ENSG00000146938	ENST00000381092	A0A024RBV0
ENSG00000146938	ENST00000381093	Q8N0W4
ENSG00000146938	ENST00000381093	A0A024RBV0
ENSG00000146938	ENST00000381095	Q8N0W4
ENSG00000146938	ENST00000381095	A0A024RBV0
ENSG00000146938	ENST00000469740	A0A2R8YCI5
ENSG00000146938	ENST00000483337	A0A2R8Y6F7
ENSG00000146938	ENST00000538097	Q8N0W4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Neuronal System	REACTOME	R-HSA-112316
Protein-protein interactions at synapses	REACTOME	R-HSA-6794362
Interactions of neurexins and neuroligins at synapses	REACTOME	R-HSA-6794361

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12669065	2003	Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.	572
19736351	2009	Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.	151
15622415	2005	Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients.	110
18231125	2008	Familial deletion within NLGN4 associated with autism and Tourette syndrome.	99
19598235	2009	Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.	92
19598235	2009	Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.	92
19726642	2009	A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export.	72
16648374	2006	Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism.	63
21278334	2011	Investigating synapse formation and function using human pluripotent stem cell-derived neurons.	63
16077734	2005	Analysis of four neuroligin genes as candidates for autism.	48

Citation

Dessen P

NLGN4X (neuroligin 4 X-linked)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55987/nlgn4x