NLRP10 (NLR family pyrin domain containing 10)

2014-11-01  

Identity

HGNC
NLRP10
LOCATION
11p15.4
LOCUSID
338322
ALIAS
CLR11.1,NALP10,NOD8,PAN5,PYNOD

Other Information

Locus ID:

NCBI: 338322
MIM: 609662
HGNC: 21464
Ensembl: ENSG00000182261

Variants:

dbSNP: 338322
ClinVar: 338322
TCGA: ENSG00000182261
COSMIC: NLRP10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182261ENST00000328600Q86W26
ENSG00000182261ENST00000526590E9PPY0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
158174832005PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.45
204031352010The genetics of NOD-like receptors in Crohn's disease.21
223659662012Functional characterization of the p53 binding site in the human PYNOD promoter.1
150964762004PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.0
195440932009A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence.0
203931372010Anti-inflammatory activity of PYNOD and its mechanism in humans and mice.0
226722332012NLRP10 enhances Shigella-induced pro-inflammatory responses.0
235626142013Roles of NLRP10 in innate and adaptive immunity.0
287669902017Involvement of NLRP10 in IL-1α induction of oral epithelial cells by periodontal pathogens.0
295015742018Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms.0

Citation

Dessen P

NLRP10 (NLR family pyrin domain containing 10)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70871/nlrp10