NLRP11 (NLR family pyrin domain containing 11)

2019-04-01  

Identity

HGNC
NLRP11
LOCATION
19q13.42
LOCUSID
204801
ALIAS
CLR19.6,NALP11,NOD17,PAN10,PYPAF6,PYPAF7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 204801
MIM: 609664
HGNC: 22945
Ensembl: ENSG00000179873

Variants:

dbSNP: 204801
ClinVar: 204801
TCGA: ENSG00000179873
COSMIC: NLRP11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179873ENST00000589093P59045
ENSG00000179873ENST00000589824P59045
ENSG00000179873ENST00000590409K7EMN8
ENSG00000179873ENST00000592953P59045
ENSG00000179873ENST00000593208K7ESF9
ENSG00000179873ENST00000593244K7EQV0

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
190748852008Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.25
204031352010The genetics of NOD-like receptors in Crohn's disease.21
290973932017NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis.3
293019402018The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling.3

Citation

Dessen P

NLRP11 (NLR family pyrin domain containing 11)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57948/nlrp11