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NLRP2B (NLR family pyrin domain containing 2B)

Identity

Alias_namesNLRP2P
NLR family, pyrin domain containing 2 pseudogene
Alias_symbol (synonym)NOD24
NALP2P
CLRX.1
POP4
Other alias
HGNC (Hugo) NLRP2B
LocusID (NCBI) 286430
Atlas_Id 55808
Location Xp11.21  [Link to chromosome band Xp11]
Location_base_pair Starts at 57677067 and ends at 57680260 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLRP2B   29887
Cards
Entrez_Gene (NCBI)NLRP2B  286430  NLR family pyrin domain containing 2B
AliasesCLRX.1; NALP2P; NLRP2P; NOD24; 
POP4
GeneCards (Weizmann)NLRP2B
Ensembl hg19 (Hinxton)ENSG00000215174 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000215174 [Gene_View]  ENSG00000215174 [Sequence]  chrX:57677067-57680260 [Contig_View]  NLRP2B [Vega]
ICGC DataPortalENSG00000215174
TCGA cBioPortalNLRP2B
AceView (NCBI)NLRP2B
Genatlas (Paris)NLRP2B
WikiGenes286430
SOURCE (Princeton)NLRP2B
Genetics Home Reference (NIH)NLRP2B
Genomic and cartography
GoldenPath hg38 (UCSC)NLRP2B  -     chrX:57677067-57680260 -  Xp11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLRP2B  -     Xp11.21   [Description]    (hg19-Feb_2009)
GoldenPathNLRP2B - Xp11.21 [CytoView hg19]  NLRP2B - Xp11.21 [CytoView hg38]
Genome Data Viewer NCBINLRP2B [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK026387
RefSeq transcript (Entrez)NM_001319967
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NLRP2B
Alternative Splicing GalleryENSG00000215174
Gene ExpressionNLRP2B [ NCBI-GEO ]   NLRP2B [ EBI - ARRAY_EXPRESS ]   NLRP2B [ SEEK ]   NLRP2B [ MEM ]
Gene Expression Viewer (FireBrowse)NLRP2B [ Firebrowse - Broad ]
GenevisibleExpression of NLRP2B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)286430
GTEX Portal (Tissue expression)NLRP2B
Human Protein AtlasENSG00000215174-NLRP2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0DMW2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0DMW2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0DMW2
Splice isoforms : SwissVarP0DMW2
PhosPhoSitePlusP0DMW2
Domains : Interpro (EBI)DEATH-like_dom_sf   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)NLRP2B
DMDM Disease mutations286430
SuperfamilyP0DMW2
Human Protein Atlas [tissue]ENSG00000215174-NLRP2B [tissue]
Peptide AtlasP0DMW2
Protein Interaction databases
DIP (DOE-UCLA)P0DMW2
IntAct (EBI)P0DMW2
FunCoupENSG00000215174
BioGRIDNLRP2B
STRING (EMBL)NLRP2B
ZODIACNLRP2B
Ontologies - Pathways
QuickGOP0DMW2
Ontology : AmiGOnucleus  cytoplasm  negative regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  negative regulation of peptidyl-serine phosphorylation  negative regulation of toll-like receptor signaling pathway  positive regulation of apoptotic process  innate immune response  negative regulation of cell cycle  negative regulation of interleukin-1 beta secretion  positive regulation of interleukin-1 beta secretion  negative regulation of NLRP3 inflammasome complex assembly  
Ontology : EGO-EBInucleus  cytoplasm  negative regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  negative regulation of peptidyl-serine phosphorylation  negative regulation of toll-like receptor signaling pathway  positive regulation of apoptotic process  innate immune response  negative regulation of cell cycle  negative regulation of interleukin-1 beta secretion  positive regulation of interleukin-1 beta secretion  negative regulation of NLRP3 inflammasome complex assembly  
NDEx NetworkNLRP2B
Atlas of Cancer Signalling NetworkNLRP2B
Wikipedia pathwaysNLRP2B
Orthology - Evolution
OrthoDB286430
GeneTree (enSembl)ENSG00000215174
Phylogenetic Trees/Animal Genes : TreeFamNLRP2B
HOGENOMP0DMW2
Homologs : HomoloGeneNLRP2B
Homology/Alignments : Family Browser (UCSC)NLRP2B
Gene fusions - Rearrangements
Fusion : QuiverNLRP2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLRP2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLRP2B
dbVarNLRP2B
ClinVarNLRP2B
1000_GenomesNLRP2B 
Exome Variant ServerNLRP2B
GNOMAD BrowserENSG00000215174
Varsome BrowserNLRP2B
Genetic variants : HAPMAP286430
Genomic Variants (DGV)NLRP2B [DGVbeta]
DECIPHERNLRP2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLRP2B 
Mutations
ICGC Data PortalNLRP2B 
TCGA Data PortalNLRP2B 
Broad Tumor PortalNLRP2B
OASIS PortalNLRP2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLRP2B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNLRP2B
Mutations and Diseases : HGMDNLRP2B
BioMutaselect NLRP2B
DgiDB (Drug Gene Interaction Database)NLRP2B
DoCM (Curated mutations)NLRP2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLRP2B (select a term)
intoGenNLRP2B
Cancer3DNLRP2B (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETNLRP2B
MedgenNLRP2B
Genetic Testing Registry NLRP2B
NextProtP0DMW2 [Medical]
TSGene286430
GENETestsNLRP2B
Open Targets GeneticsENSG00000215174  [validation]
snp3D : Map Gene to Disease286430
BioCentury BCIQNLRP2B
ClinGenNLRP2B
Clinical trials, drugs, therapy
Protein Interactions : CTD286430
Pharm GKB GenePA166181581
Clinical trialNLRP2B
Miscellaneous
canSAR (ICR)NLRP2B (select the gene name)
HarmonizomeNLRP2B
DataMed IndexNLRP2B
Probes
Litterature
PubMed4 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLRP2B
EVEXNLRP2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:02:32 CEST 2020

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