Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NLRP4 (NLR family pyrin domain containing 4)

Identity

Alias_namesNALP4
NACHT, leucine rich repeat and PYD containing 4
Alias_symbol (synonym)PYPAF4
FLJ32126
PAN2
RNH2
CLR19.5
CT58
Other alias
HGNC (Hugo) NLRP4
LocusID (NCBI) 147945
Atlas_Id 70876
Location 19q13.43  [Link to chromosome band 19q13]
Location_base_pair Starts at 55836578 and ends at 55881854 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RUNX1 (21q22.12) / NLRP4 (19q13.43)ZNF331 (19q13.42) / NLRP4 (19q13.43)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NLRP4   22943
Cards
Entrez_Gene (NCBI)NLRP4  147945  NLR family pyrin domain containing 4
AliasesCLR19.5; CT58; NALP4; PAN2; 
PYPAF4; RNH2
GeneCards (Weizmann)NLRP4
Ensembl hg19 (Hinxton)ENSG00000160505 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160505 [Gene_View]  ENSG00000160505 [Sequence]  chr19:55836578-55881854 [Contig_View]  NLRP4 [Vega]
ICGC DataPortalENSG00000160505
TCGA cBioPortalNLRP4
AceView (NCBI)NLRP4
Genatlas (Paris)NLRP4
WikiGenes147945
SOURCE (Princeton)NLRP4
Genetics Home Reference (NIH)NLRP4
Genomic and cartography
GoldenPath hg38 (UCSC)NLRP4  -     chr19:55836578-55881854 +  19q13.43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLRP4  -     19q13.43   [Description]    (hg19-Feb_2009)
GoldenPathNLRP4 - 19q13.43 [CytoView hg19]  NLRP4 - 19q13.43 [CytoView hg38]
ImmunoBaseENSG00000160505
Mapping of homologs : NCBINLRP4 [Mapview hg19]  NLRP4 [Mapview hg38]
OMIM609645   
Gene and transcription
Genbank (Entrez)AF442488 AF479747 AF482706 AK056688 AK315003
RefSeq transcript (Entrez)NM_134444
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NLRP4
Cluster EST : UnigeneHs.631533 [ NCBI ]
CGAP (NCI)Hs.631533
Alternative Splicing GalleryENSG00000160505
Gene ExpressionNLRP4 [ NCBI-GEO ]   NLRP4 [ EBI - ARRAY_EXPRESS ]   NLRP4 [ SEEK ]   NLRP4 [ MEM ]
Gene Expression Viewer (FireBrowse)NLRP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)147945
GTEX Portal (Tissue expression)NLRP4
Human Protein AtlasENSG00000160505-NLRP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96MN2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96MN2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96MN2
Splice isoforms : SwissVarQ96MN2
PhosPhoSitePlusQ96MN2
Domaine pattern : Prosite (Expaxy)DAPIN (PS50824)    NACHT (PS50837)   
Domains : Interpro (EBI)DAPIN    DEATH-like_dom_sf    Leu-rich_rpt    LRR_dom_sf    NACHT_NTPase    P-loop_NTPase   
Domain families : Pfam (Sanger)LRR_6 (PF13516)    PYRIN (PF02758)   
Domain families : Pfam (NCBI)pfam13516    pfam02758   
Domain families : Smart (EMBL)PYRIN (SM01289)  
Conserved Domain (NCBI)NLRP4
DMDM Disease mutations147945
Blocks (Seattle)NLRP4
PDB (RSDB)4EWI   
PDB Europe4EWI   
PDB (PDBSum)4EWI   
PDB (IMB)4EWI   
Structural Biology KnowledgeBase4EWI   
SCOP (Structural Classification of Proteins)4EWI   
CATH (Classification of proteins structures)4EWI   
SuperfamilyQ96MN2
Human Protein Atlas [tissue]ENSG00000160505-NLRP4 [tissue]
Peptide AtlasQ96MN2
HPRD09619
IPIIPI00151977   IPI00218614   IPI00218615   
Protein Interaction databases
DIP (DOE-UCLA)Q96MN2
IntAct (EBI)Q96MN2
FunCoupENSG00000160505
BioGRIDNLRP4
STRING (EMBL)NLRP4
ZODIACNLRP4
Ontologies - Pathways
QuickGOQ96MN2
Ontology : AmiGOATP binding  cytosol  inflammatory response  regulation of type I interferon production  
Ontology : EGO-EBIATP binding  cytosol  inflammatory response  regulation of type I interferon production  
NDEx NetworkNLRP4
Atlas of Cancer Signalling NetworkNLRP4
Wikipedia pathwaysNLRP4
Orthology - Evolution
OrthoDB147945
GeneTree (enSembl)ENSG00000160505
Phylogenetic Trees/Animal Genes : TreeFamNLRP4
HOGENOMQ96MN2
Homologs : HomoloGeneNLRP4
Homology/Alignments : Family Browser (UCSC)NLRP4
Gene fusions - Rearrangements
Fusion : QuiverNLRP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLRP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLRP4
dbVarNLRP4
ClinVarNLRP4
1000_GenomesNLRP4 
Exome Variant ServerNLRP4
ExAC (Exome Aggregation Consortium)ENSG00000160505
GNOMAD BrowserENSG00000160505
Varsome BrowserNLRP4
Genetic variants : HAPMAP147945
Genomic Variants (DGV)NLRP4 [DGVbeta]
DECIPHERNLRP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLRP4 
Mutations
ICGC Data PortalNLRP4 
TCGA Data PortalNLRP4 
Broad Tumor PortalNLRP4
OASIS PortalNLRP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLRP4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNLRP4
Mutations and Diseases : HGMDNLRP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NLRP4
DgiDB (Drug Gene Interaction Database)NLRP4
DoCM (Curated mutations)NLRP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLRP4 (select a term)
intoGenNLRP4
Cancer3DNLRP4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609645   
Orphanet
DisGeNETNLRP4
MedgenNLRP4
Genetic Testing Registry NLRP4
NextProtQ96MN2 [Medical]
TSGene147945
GENETestsNLRP4
Target ValidationNLRP4
Huge Navigator NLRP4 [HugePedia]
snp3D : Map Gene to Disease147945
BioCentury BCIQNLRP4
ClinGenNLRP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD147945
Chemical/Pharm GKB GenePA162397947
Clinical trialNLRP4
Miscellaneous
canSAR (ICR)NLRP4 (select the gene name)
DataMed IndexNLRP4
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLRP4
EVEXNLRP4
GoPubMedNLRP4
iHOPNLRP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Sep 3 15:57:52 CEST 2019
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