NLRX1 (NLR family member X1)

2015-09-01  

Identity

HGNC
NLRX1
LOCATION
11q23.3
LOCUSID
79671
ALIAS
CLR11.3,DLNB26,NOD26,NOD5,NOD9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79671
MIM: 611947
HGNC: 29890
Ensembl: ENSG00000160703

Variants:

dbSNP: 79671
ClinVar: 79671
TCGA: ENSG00000160703
COSMIC: NLRX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160703ENST00000292199Q86UT6
ENSG00000160703ENST00000409109Q86UT6
ENSG00000160703ENST00000409265Q86UT6
ENSG00000160703ENST00000409991Q86UT6
ENSG00000160703ENST00000422249C9JLK8
ENSG00000160703ENST00000449394C9JQE9
ENSG00000160703ENST00000454811C9J0R6
ENSG00000160703ENST00000525863Q86UT6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182000102008NLRX1 is a regulator of mitochondrial antiviral immunity.222
182193132008NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production.113
227493522012The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.106
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
196925912009An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix.65
209594522010Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1.57
223865892012Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator.33
244293602014Nod-like receptor X-1 is required for rhinovirus-induced barrier dysfunction in airway epithelial cells.29
233215572013The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy.26
267639802016Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure.23

Citation

Dessen P

NLRX1 (NLR family member X1)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55406/nlrx1