NME3 (NME/NM23 nucleoside diphosphate kinase 3)

2003-02-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
DR-nm23,NDPK-C,NDPKC,NM23-H3,NM23H3,c371H6.2
FUSION GENES

Other Information

Locus ID:

NCBI: 4832
MIM: 601817
HGNC: 7851
Ensembl: ENSG00000103024

Variants:

dbSNP: 4832
ClinVar: 4832
TCGA: ENSG00000103024
COSMIC: NME3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103024ENST00000219302Q13232
ENSG00000103024ENST00000563498H3BPR2
ENSG00000103024ENST00000563854H3BMQ7
ENSG00000103024ENST00000564628H3BRA8
ENSG00000103024ENST00000568561H3BPD9

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGM00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGhsa_M00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
179005112007Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma.9
269450152016The direct interaction of NME3 with Tip60 in DNA repair.6
237650942013Inhibitory effect of upregulated DR-nm23 expression on invasion and metastasis in colorectal cancer.3
295237662018Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NFκB Activation.2
301115922018The nucleoside-diphosphate kinase NME3 associates with nephronophthisis proteins and is required for ciliary function during renal development.2
305875872019Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.2

Citation

Dessen P

NME3 (NME/NM23 nucleoside diphosphate kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41545/nme3