NME7 (NME/NM23 family member 7)

2014-11-01  

Identity

HGNC
LOCATION
1q24.2
LOCUSID
ALIAS
CFAP67,MN23H7,NDK 7,NDK7,nm23-H7
FUSION GENES

Other Information

Locus ID:

NCBI: 29922
MIM: 613465
HGNC: 20461
Ensembl: ENSG00000143156

Variants:

dbSNP: 29922
ClinVar: 29922
TCGA: ENSG00000143156
COSMIC: NME7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143156ENST00000367811Q9Y5B8
ENSG00000143156ENST00000472647Q9Y5B8
ENSG00000143156ENST00000472647A0A024R8Z7
ENSG00000143156ENST00000525440B4DXC8
ENSG00000143156ENST00000528517E9PNU1

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGM00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGhsa_M00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
248079052014NME7 is a functional component of the γ-tubulin ring complex.19
173637022007Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein beta gamma dimer complexes.17
190646102009Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.16
267494262016A Primitive Growth Factor, NME7AB , Is Sufficient to Induce Stable Naïve State Human Pluripotency; Reprogramming in This Novel Growth Factor Confers Superior Differentiation.9
270604912016A Homozygous Nme7 Mutation Is Associated with Situs Inversus Totalis.4

Citation

Dessen P

NME7 (NME/NM23 family member 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70885/nme7