NME8 (NME/NM23 family member 8)

2014-11-01  

Identity

HGNC
NME8
LOCATION
7p14.1
LOCUSID
51314
ALIAS
CILD6,DNAI8,HEL-S-99,NM23-H8,SPTRX2,TXNDC3,sptrx-2

Other Information

Locus ID:

NCBI: 51314
MIM: 607421
HGNC: 16473
Ensembl: ENSG00000086288

Variants:

dbSNP: 51314
ClinVar: 51314
TCGA: ENSG00000086288
COSMIC: NME8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086288ENST00000199447Q8N427
ENSG00000086288ENST00000426106F8WEA2
ENSG00000086288ENST00000440017Q8N427
ENSG00000086288ENST00000444718C9JG62
ENSG00000086288ENST00000455500C9JIT0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
173606482007A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia.73
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
166424352006Cis- and trans-acting gene regulation is associated with osteoarthritis.27
256728912015A genome-wide association study of periodontitis in a Japanese population.14
254861182014Association between NME8 locus polymorphism and cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease.12
184713222008Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis.10
184713222008Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis.10
173047102007Genetic association analysis of RHOB and TXNDC3 in osteoarthritis.6
173047102007Genetic association analysis of RHOB and TXNDC3 in osteoarthritis.6
202371512010Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system.4

Citation

Dessen P

NME8 (NME/NM23 family member 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70886/nme8