NMU (neuromedin U)

2007-02-01  

Identity

HGNC
LOCATION
4q12
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 10874
MIM: 605103
HGNC: 7859
Ensembl: ENSG00000109255

Variants:

dbSNP: 10874
ClinVar: 10874
TCGA: ENSG00000109255
COSMIC: NMU

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109255ENST00000264218P48645
ENSG00000109255ENST00000264218A0A250SH36
ENSG00000109255ENST00000505262D6RBC9
ENSG00000109255ENST00000507338E9PDJ7
ENSG00000109255ENST00000511469A0A0B4J202

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
168781522007Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia.29
170185952006The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer.29
195197562009Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S.28
291071082018Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U.26
153317682004Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction.23
191189412009Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway.21
146232742003Central actions of neuromedin U via corticotropin-releasing hormone.20
151870202004Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias.20
169849852006Association between neuromedin U gene variants and overweight and obesity.17

Citation

Dessen P

NMU (neuromedin U)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45881/nmu