Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NOC4L (nucleolar complex associated 4 homolog)

Identity

Alias_namesnucleolar complex associated 4 homolog (S. cerevisiae)
Alias_symbol (synonym)MGC3162
NET49
UTP19
Noc4
Other aliasNOC4
HGNC (Hugo) NOC4L
LocusID (NCBI) 79050
Atlas_Id 54505
Location 12q24.33  [Link to chromosome band 12q24]
Location_base_pair Starts at 132144457 and ends at 132152468 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGRN (1p36.33) / NOC4L (12q24.33)ANKLE2 (12q24.33) / NOC4L (12q24.33)ERF (19q13.2) / NOC4L (12q24.33)
NOC4L (12q24.33) / FAM129A (1q25.3)NOC4L (12q24.33) / FBRSL1 (12q24.33)NOC4L (12q24.33) / PTOV1 (19q13.33)
NOC4L (12q24.33) / RAB3GAP2 (1q41)NOC4L (12q24.33) / SDS (12q24.13)NOC4L (12q24.33) / STAB2 (12q23.3)
PANK4 (1p36.32) / NOC4L (12q24.33)SAMD11 (1p36.33) / NOC4L (12q24.33)TTYH3 (7p22.3) / NOC4L (12q24.33)
AGRN 1p36.33 / NOC4L 12q24.33NOC4L 12q24.33 / SDS 12q24.13NOC4L 12q24.33 / STAB2 12q23.3
TTYH3 7p22.3 / NOC4L 12q24.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(q24;q24) NOC4L/FBRSL1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(1;12)(p36;q24) AGRN/NOC4L
t(7;12)(p22;q24) TTYH3/NOC4L
t(12;12)(q23;q24) NOC4L/STAB2
NOC4L/SDS (12q24)

External links

Nomenclature
HGNC (Hugo)NOC4L   28461
Cards
Entrez_Gene (NCBI)NOC4L  79050  nucleolar complex associated 4 homolog
AliasesNET49; NOC4; UTP19
GeneCards (Weizmann)NOC4L
Ensembl hg19 (Hinxton)ENSG00000184967 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184967 [Gene_View]  ENSG00000184967 [Sequence]  chr12:132144457-132152468 [Contig_View]  NOC4L [Vega]
ICGC DataPortalENSG00000184967
TCGA cBioPortalNOC4L
AceView (NCBI)NOC4L
Genatlas (Paris)NOC4L
WikiGenes79050
SOURCE (Princeton)NOC4L
Genetics Home Reference (NIH)NOC4L
Genomic and cartography
GoldenPath hg38 (UCSC)NOC4L  -     chr12:132144457-132152468 +  12q24.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOC4L  -     12q24.33   [Description]    (hg19-Feb_2009)
GoldenPathNOC4L - 12q24.33 [CytoView hg19]  NOC4L - 12q24.33 [CytoView hg38]
ImmunoBaseENSG00000184967
Mapping of homologs : NCBINOC4L [Mapview hg19]  NOC4L [Mapview hg38]
OMIM612819   
Gene and transcription
Genbank (Entrez)AW731886 BC001191 BC007893 BC071958 HY051629
RefSeq transcript (Entrez)NM_024078
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOC4L
Alternative Splicing GalleryENSG00000184967
Gene ExpressionNOC4L [ NCBI-GEO ]   NOC4L [ EBI - ARRAY_EXPRESS ]   NOC4L [ SEEK ]   NOC4L [ MEM ]
Gene Expression Viewer (FireBrowse)NOC4L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79050
GTEX Portal (Tissue expression)NOC4L
Human Protein AtlasENSG00000184967-NOC4L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BVI4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BVI4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BVI4
Splice isoforms : SwissVarQ9BVI4
PhosPhoSitePlusQ9BVI4
Domains : Interpro (EBI)ARM-type_fold    CCAAT-binding_factor    Noc4   
Domain families : Pfam (Sanger)CBF (PF03914)   
Domain families : Pfam (NCBI)pfam03914   
Conserved Domain (NCBI)NOC4L
DMDM Disease mutations79050
Blocks (Seattle)NOC4L
SuperfamilyQ9BVI4
Human Protein Atlas [tissue]ENSG00000184967-NOC4L [tissue]
Peptide AtlasQ9BVI4
HPRD14543
IPIIPI00031661   IPI01015153   IPI01014662   
Protein Interaction databases
DIP (DOE-UCLA)Q9BVI4
IntAct (EBI)Q9BVI4
FunCoupENSG00000184967
BioGRIDNOC4L
STRING (EMBL)NOC4L
ZODIACNOC4L
Ontologies - Pathways
QuickGOQ9BVI4
Ontology : AmiGORNA binding  protein binding  nucleoplasm  nucleoplasm  nucleolus  nucleolus  nucleolus  rRNA processing  rRNA processing  integral component of membrane  Noc4p-Nop14p complex  nuclear membrane  small-subunit processome  
Ontology : EGO-EBIRNA binding  protein binding  nucleoplasm  nucleoplasm  nucleolus  nucleolus  nucleolus  rRNA processing  rRNA processing  integral component of membrane  Noc4p-Nop14p complex  nuclear membrane  small-subunit processome  
NDEx NetworkNOC4L
Atlas of Cancer Signalling NetworkNOC4L
Wikipedia pathwaysNOC4L
Orthology - Evolution
OrthoDB79050
GeneTree (enSembl)ENSG00000184967
Phylogenetic Trees/Animal Genes : TreeFamNOC4L
HOGENOMQ9BVI4
Homologs : HomoloGeneNOC4L
Homology/Alignments : Family Browser (UCSC)NOC4L
Gene fusions - Rearrangements
Fusion : MitelmanAGRN/NOC4L [1p36.33/12q24.33]  [t(1;12)(p36;q24)]  
Fusion : MitelmanNOC4L/SDS [12q24.33/12q24.13]  [t(12;12)(q24;q24)]  
Fusion : MitelmanNOC4L/STAB2 [12q24.33/12q23.3]  [t(12;12)(q23;q24)]  
Fusion : MitelmanTTYH3/NOC4L [7p22.3/12q24.33]  [t(7;12)(p22;q24)]  
Fusion PortalAGRN 1p36.33 NOC4L 12q24.33 BRCA LUSC
Fusion PortalNOC4L 12q24.33 SDS 12q24.13 GBM
Fusion PortalNOC4L 12q24.33 STAB2 12q23.3 LUSC
Fusion PortalTTYH3 7p22.3 NOC4L 12q24.33 SKCM
Fusion : QuiverNOC4L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOC4L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOC4L
dbVarNOC4L
ClinVarNOC4L
1000_GenomesNOC4L 
Exome Variant ServerNOC4L
ExAC (Exome Aggregation Consortium)ENSG00000184967
GNOMAD BrowserENSG00000184967
Varsome BrowserNOC4L
Genetic variants : HAPMAP79050
Genomic Variants (DGV)NOC4L [DGVbeta]
DECIPHERNOC4L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOC4L 
Mutations
ICGC Data PortalNOC4L 
TCGA Data PortalNOC4L 
Broad Tumor PortalNOC4L
OASIS PortalNOC4L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOC4L  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNOC4L
Mutations and Diseases : HGMDNOC4L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NOC4L
DgiDB (Drug Gene Interaction Database)NOC4L
DoCM (Curated mutations)NOC4L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOC4L (select a term)
intoGenNOC4L
Cancer3DNOC4L(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612819   
Orphanet
DisGeNETNOC4L
MedgenNOC4L
Genetic Testing Registry NOC4L
NextProtQ9BVI4 [Medical]
TSGene79050
GENETestsNOC4L
Target ValidationNOC4L
Huge Navigator NOC4L [HugePedia]
snp3D : Map Gene to Disease79050
BioCentury BCIQNOC4L
ClinGenNOC4L
Clinical trials, drugs, therapy
Protein Interactions : CTD79050
Pharm GKB GenePA142671262
Clinical trialNOC4L
Miscellaneous
canSAR (ICR)NOC4L (select the gene name)
HarmonizomeNOC4L
DataMed IndexNOC4L
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOC4L
EVEXNOC4L
GoPubMedNOC4L
iHOPNOC4L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Jun 30 20:25:20 CEST 2020
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