NOCT (nocturnin)

2007-02-01 Affiliation

Identity

HGNC

NOCT

LOCATION

4q31.1

LOCUSID

25819

ALIAS

CCR4L,CCRN4L,Ccr4c,NOC

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 25819
MIM: 608468
HGNC: 14254
Ensembl: ENSG00000151014

Variants:

dbSNP: 25819
ClinVar: 25819
TCGA: ENSG00000151014
COSMIC: NOCT

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000151014	ENST00000280614	Q9UK39
ENSG00000151014	ENST00000630479	Q8WTX0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Circadian Clock	REACTOME	R-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expression	REACTOME	R-HSA-1368108

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16821125	2006	RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4.	33
18587630	2008	CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter.	13
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
24821610	2014	Association between CLOCK, PER3 and CCRN4L with non‑small cell lung cancer in Brazilian patients.	11
26541675	2015	Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression.	8
23922759	2013	Genetic variation in the NOC gene is associated with body mass index in Chinese subjects.	7
29860338	2018	The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.	6
30389976	2018	Crystal Structure of Human Nocturnin Catalytic Domain.	4
22547059	2012	RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway.	1

Citation

Dessen P

NOCT (nocturnin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46547/noct