NOD1 (nucleotide binding oligomerization domain containing 1)

2003-08-01  

Identity

HGNC
LOCATION
7p14.3
LOCUSID
ALIAS
CARD4,CLR7.1,NLRC1
FUSION GENES

Other Information

Locus ID:

NCBI: 10392
MIM: 605980
HGNC: 16390
Ensembl: ENSG00000106100

Variants:

dbSNP: 10392
ClinVar: 10392
TCGA: ENSG00000106100
COSMIC: NOD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106100ENST00000222823Q9Y239
ENSG00000106100ENST00000222823A0A024RA73
ENSG00000106100ENST00000411552A0A1B0GX71
ENSG00000106100ENST00000413433A0A1B0GX71
ENSG00000106100ENST00000419601C9J8X8
ENSG00000106100ENST00000419799A0A1B0GX71
ENSG00000106100ENST00000434755G3XAL1

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
ShigellosisKEGGhsa05131
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
PertussisKEGGko05133
PertussisKEGGhsa05133
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
TAK1 activates NFkB by phosphorylation and activation of IKKs complexREACTOMER-HSA-445989
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1REACTOMER-HSA-450321
activated TAK1 mediates p38 MAPK activationREACTOMER-HSA-450302
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
NOD1/2 Signaling PathwayREACTOMER-HSA-168638
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

References

Pubmed IDYearTitleCitations
365443562023Association of NOD1 and NOD2 Polymorphisms With Susceptibility to Subacute Sclerosing Panencephalitis.0
366576402023NOD1 activation in 3T3-L1 adipocytes confers lipid accumulation in HepG2 cells.1
372246602023NOD1 mediated D. pteronyssinus-induced allergic airway inflammation through RIP2/NF-κB.0
373504452023Association between genetic polymorphisms of NOD1, Interleukin-1B, and cagA strain with low-grade duodenal eosinophilia in Helicobacter pylori-related dyspepsia.1
374889672023NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-ĸB-independent manner.1
379964572023Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases.2
365443562023Association of NOD1 and NOD2 Polymorphisms With Susceptibility to Subacute Sclerosing Panencephalitis.0
366576402023NOD1 activation in 3T3-L1 adipocytes confers lipid accumulation in HepG2 cells.1
372246602023NOD1 mediated D. pteronyssinus-induced allergic airway inflammation through RIP2/NF-κB.0
373504452023Association between genetic polymorphisms of NOD1, Interleukin-1B, and cagA strain with low-grade duodenal eosinophilia in Helicobacter pylori-related dyspepsia.1
374889672023NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-ĸB-independent manner.1
379964572023Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases.2
348259312022Activation of RIPK2-mediated NOD1 signaling promotes proliferation and invasion of ovarian cancer cells via NF-κB pathway.6
350335912022Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway.32
351309022022Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer.7

Citation

Dessen P

NOD1 (nucleotide binding oligomerization domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/912/nod1