NOG (noggin)

2003-12-01  

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
SYM1,SYNS1,SYNS1A

Other Information

Locus ID:

NCBI: 9241
MIM: 602991
HGNC: 7866
Ensembl: ENSG00000183691

Variants:

dbSNP: 9241
ClinVar: 9241
TCGA: ENSG00000183691
COSMIC: NOG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183691ENST00000332822Q13253

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124782852002Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.137
149990642004Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone.57
161264632006Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions.51
185371412008Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit.45
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
200481502010Identification of a key residue mediating bone morphogenetic protein (BMP)-6 resistance to noggin inhibition allows for engineered BMPs with superior agonist activity.33
172186032007The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis.28
172001912007Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases.24
264138862016Imbalance Between Bone Morphogenetic Protein 2 and Noggin Induces Abnormal Osteogenic Differentiation of Mesenchymal Stem Cells in Ankylosing Spondylitis.24
197007582009Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways.23

Citation

Dessen P

NOG (noggin)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41551/nog