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NOTCH2NLA (notch 2 N-terminal like A)

Identity

Other aliasN2N
NOTCH2NL
HGNC (Hugo) NOTCH2NLA
LocusID (NCBI) 388677
Atlas_Id 80439
Location 1q21.1  [Link to chromosome band 1q21]
Location_base_pair Starts at 146151908 and ends at 146229032 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)NOTCH2NLA   31862
Cards
Entrez_Gene (NCBI)NOTCH2NLA  388677  notch 2 N-terminal like A
AliasesN2N; NOTCH2NL
GeneCards (Weizmann)NOTCH2NLA
Ensembl hg19 (Hinxton)ENSG00000264343 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000264343 [Gene_View]  ENSG00000264343 [Sequence]  chr1:146151908-146229032 [Contig_View]  NOTCH2NLA [Vega]
ICGC DataPortalENSG00000264343
TCGA cBioPortalNOTCH2NLA
AceView (NCBI)NOTCH2NLA
Genatlas (Paris)NOTCH2NLA
WikiGenes388677
SOURCE (Princeton)NOTCH2NLA
Genetics Home Reference (NIH)NOTCH2NLA
Genomic and cartography
GoldenPath hg38 (UCSC)NOTCH2NLA  -     chr1:146151908-146229032 -  1q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOTCH2NLA  -     1q21.1   [Description]    (hg19-Feb_2009)
GoldenPathNOTCH2NLA - 1q21.1 [CytoView hg19]  NOTCH2NLA - 1q21.1 [CytoView hg38]
ImmunoBaseENSG00000264343
Mapping of homologs : NCBINOTCH2NLA [Mapview hg19]  NOTCH2NLA [Mapview hg38]
OMIM618023   
Gene and transcription
Genbank (Entrez)AK000887 AK022008 AK075065 AL833369 BC010154
RefSeq transcript (Entrez)NM_001364006 NM_203458
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOTCH2NLA
Cluster EST : UnigeneHs.728902 [ NCBI ]
CGAP (NCI)Hs.728902
Alternative Splicing GalleryENSG00000264343
Gene ExpressionNOTCH2NLA [ NCBI-GEO ]   NOTCH2NLA [ EBI - ARRAY_EXPRESS ]   NOTCH2NLA [ SEEK ]   NOTCH2NLA [ MEM ]
Gene Expression Viewer (FireBrowse)NOTCH2NLA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)388677
GTEX Portal (Tissue expression)NOTCH2NLA
Human Protein AtlasENSG00000264343-NOTCH2NLA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z3S9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z3S9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z3S9
Splice isoforms : SwissVarQ7Z3S9
PhosPhoSitePlusQ7Z3S9
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS   
Domain families : Pfam (Sanger)EGF (PF00008)    EGF_CA (PF07645)   
Domain families : Pfam (NCBI)pfam00008    pfam07645   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)NOTCH2NLA
DMDM Disease mutations388677
Blocks (Seattle)NOTCH2NLA
SuperfamilyQ7Z3S9
Human Protein Atlas [tissue]ENSG00000264343-NOTCH2NLA [tissue]
Peptide AtlasQ7Z3S9
IPIIPI00515007   IPI00843817   IPI00335544   IPI00983804   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z3S9
IntAct (EBI)Q7Z3S9
FunCoupENSG00000264343
BioGRIDNOTCH2NLA
STRING (EMBL)NOTCH2NLA
ZODIACNOTCH2NLA
Ontologies - Pathways
QuickGOQ7Z3S9
Ontology : AmiGONotch binding  Notch binding  calcium ion binding  protein binding  extracellular region  cytoplasm  plasma membrane  Notch signaling pathway  cerebral cortex development  cell differentiation  positive regulation of Notch signaling pathway  
Ontology : EGO-EBINotch binding  Notch binding  calcium ion binding  protein binding  extracellular region  cytoplasm  plasma membrane  Notch signaling pathway  cerebral cortex development  cell differentiation  positive regulation of Notch signaling pathway  
NDEx NetworkNOTCH2NLA
Atlas of Cancer Signalling NetworkNOTCH2NLA
Wikipedia pathwaysNOTCH2NLA
Orthology - Evolution
OrthoDB388677
GeneTree (enSembl)ENSG00000264343
Phylogenetic Trees/Animal Genes : TreeFamNOTCH2NLA
HOGENOMQ7Z3S9
Homologs : HomoloGeneNOTCH2NLA
Homology/Alignments : Family Browser (UCSC)NOTCH2NLA
Gene fusions - Rearrangements
Fusion : QuiverNOTCH2NLA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOTCH2NLA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOTCH2NLA
dbVarNOTCH2NLA
ClinVarNOTCH2NLA
1000_GenomesNOTCH2NLA 
Exome Variant ServerNOTCH2NLA
ExAC (Exome Aggregation Consortium)ENSG00000264343
GNOMAD BrowserENSG00000264343
Varsome BrowserNOTCH2NLA
Genetic variants : HAPMAP388677
Genomic Variants (DGV)NOTCH2NLA [DGVbeta]
DECIPHERNOTCH2NLA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOTCH2NLA 
Mutations
ICGC Data PortalNOTCH2NLA 
TCGA Data PortalNOTCH2NLA 
Broad Tumor PortalNOTCH2NLA
OASIS PortalNOTCH2NLA [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNOTCH2NLA
BioMutasearch NOTCH2NLA
DgiDB (Drug Gene Interaction Database)NOTCH2NLA
DoCM (Curated mutations)NOTCH2NLA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOTCH2NLA (select a term)
intoGenNOTCH2NLA
Cancer3DNOTCH2NLA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618023   
Orphanet
DisGeNETNOTCH2NLA
MedgenNOTCH2NLA
Genetic Testing Registry NOTCH2NLA
NextProtQ7Z3S9 [Medical]
TSGene388677
GENETestsNOTCH2NLA
Target ValidationNOTCH2NLA
Huge Navigator NOTCH2NLA [HugePedia]
snp3D : Map Gene to Disease388677
BioCentury BCIQNOTCH2NLA
ClinGenNOTCH2NLA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD388677
Chemical/Pharm GKB GenePA134983899
Clinical trialNOTCH2NLA
Miscellaneous
canSAR (ICR)NOTCH2NLA (select the gene name)
DataMed IndexNOTCH2NLA
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOTCH2NLA
EVEXNOTCH2NLA
GoPubMedNOTCH2NLA
iHOPNOTCH2NLA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Sep 3 15:57:58 CEST 2019

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