NOTUM (notum, palmitoleoyl-protein carboxylesterase)

2008-07-01 Affiliation

Identity

HGNC

NOTUM

LOCATION

17q25.3

LOCUSID

147111

ALIAS

hNOTUM

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 147111
MIM: 609847
HGNC: 27106
Ensembl: ENSG00000185269

Variants:

dbSNP: 147111
ClinVar: 147111
TCGA: ENSG00000185269
COSMIC: NOTUM

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000185269	ENST00000409678	Q6P988
ENSG00000185269	ENST00000425009	C9JYG8
ENSG00000185269	ENST00000477214	K7EIG3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Wnt signaling pathway	KEGG	ko04310
Wnt signaling pathway	KEGG	hsa04310
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog ligand biogenesis	REACTOME	R-HSA-5358346
Release of Hh-Np from the secreting cell	REACTOME	R-HSA-5362798

References

Pubmed ID	Year	Title	Citations
25731175	2015	Notum deacylates Wnt proteins to suppress signalling activity.	105
26517809	2015	Novel insights into Notum and glypicans regulation in colorectal cancer.	18
18429952	2008	Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF.	17
31292548	2019	Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.	10
30343282	2018	NOTUM Is Involved in the Progression of Colorectal Cancer.	1
31307226	2019	Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans.	0

Citation

Dessen P

NOTUM (notum, palmitoleoyl-protein carboxylesterase)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50255/notum