NOXA1 (NADPH oxidase activator 1)

2003-06-01  

Identity

HGNC
LOCATION
9q34.3
LOCUSID
ALIAS
NY-CO-31,SDCCAG31,p51NOX

Other Information

Locus ID:

NCBI: 10811
MIM: 611255
HGNC: 10668
Ensembl: ENSG00000188747

Variants:

dbSNP: 10811
ClinVar: 10811
TCGA: ENSG00000188747
COSMIC: NOXA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188747ENST00000341349Q86UR1
ENSG00000188747ENST00000392815Q86UR1

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate NADPH OxidasesREACTOMER-HSA-5668599

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
209439482010c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells.39
179137092007Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding.38
200836772010Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries.31
241871332013Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration.24
186068212008Inhibitory action of NoxA1 on dual oxidase activity in airway cells.19
204545682010Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.17
206094972011Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.16
185689542008Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells.10
202307892010Phosphorylation of serine282 in NADPH oxidase activator 1 by Erk desensitizes EGF-induced ROS generation.8
176029542007NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain.7

Citation

Dessen P

NOXA1 (NADPH oxidase activator 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41563/noxa1