Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NOXO1 (NADPH oxidase organizer 1)

Identity

Alias_symbol (synonym)P41NOXA
P41NOXB
P41NOXC
SH3PXD5
SNX28
Other aliasP41NOX
HGNC (Hugo) NOXO1
LocusID (NCBI) 124056
Atlas_Id 54846
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1978917 and ends at 1981549 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NOXO1   19404
Cards
Entrez_Gene (NCBI)NOXO1  124056  NADPH oxidase organizer 1
AliasesP41NOX; P41NOXA; P41NOXB; P41NOXC; 
SH3PXD5; SNX28
GeneCards (Weizmann)NOXO1
Ensembl hg19 (Hinxton)ENSG00000196408 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196408 [Gene_View]  ENSG00000196408 [Sequence]  chr16:1978917-1981549 [Contig_View]  NOXO1 [Vega]
ICGC DataPortalENSG00000196408
TCGA cBioPortalNOXO1
AceView (NCBI)NOXO1
Genatlas (Paris)NOXO1
WikiGenes124056
SOURCE (Princeton)NOXO1
Genetics Home Reference (NIH)NOXO1
Genomic and cartography
GoldenPath hg38 (UCSC)NOXO1  -     chr16:1978917-1981549 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOXO1  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathNOXO1 - 16p13.3 [CytoView hg19]  NOXO1 - 16p13.3 [CytoView hg38]
ImmunoBaseENSG00000196408
Mapping of homologs : NCBINOXO1 [Mapview hg19]  NOXO1 [Mapview hg38]
OMIM611256   
Gene and transcription
Genbank (Entrez)AB097667 AF532983 AF532984 AF532985 AF539796
RefSeq transcript (Entrez)NM_001267721 NM_144603 NM_172167 NM_172168
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOXO1
Cluster EST : UnigeneHs.191762 [ NCBI ]
CGAP (NCI)Hs.191762
Alternative Splicing GalleryENSG00000196408
Gene ExpressionNOXO1 [ NCBI-GEO ]   NOXO1 [ EBI - ARRAY_EXPRESS ]   NOXO1 [ SEEK ]   NOXO1 [ MEM ]
Gene Expression Viewer (FireBrowse)NOXO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)124056
GTEX Portal (Tissue expression)NOXO1
Human Protein AtlasENSG00000196408-NOXO1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFA2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFA2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFA2
Splice isoforms : SwissVarQ8NFA2
PhosPhoSitePlusQ8NFA2
Domaine pattern : Prosite (Expaxy)PX (PS50195)    SH3 (PS50002)   
Domains : Interpro (EBI)NoxO1_SH3_2    Phox    PX_dom_sf    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)PX (PF00787)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00787    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)NOXO1
DMDM Disease mutations124056
Blocks (Seattle)NOXO1
PDB (RSDB)2L73   
PDB Europe2L73   
PDB (PDBSum)2L73   
PDB (IMB)2L73   
Structural Biology KnowledgeBase2L73   
SCOP (Structural Classification of Proteins)2L73   
CATH (Classification of proteins structures)2L73   
SuperfamilyQ8NFA2
Human Protein Atlas [tissue]ENSG00000196408-NOXO1 [tissue]
Peptide AtlasQ8NFA2
HPRD14834
IPIIPI00172576   IPI00645054   IPI00396308   IPI00398839   
Protein Interaction databases
DIP (DOE-UCLA)Q8NFA2
IntAct (EBI)Q8NFA2
FunCoupENSG00000196408
BioGRIDNOXO1
STRING (EMBL)NOXO1
ZODIACNOXO1
Ontologies - Pathways
QuickGOQ8NFA2
Ontology : AmiGOprotein binding  phospholipid binding  plasma membrane  superoxide metabolic process  regulation of hydrogen peroxide metabolic process  superoxide-generating NADPH oxidase activator activity  superoxide-generating NADPH oxidase activator activity  enzyme binding  extracellular matrix disassembly  phosphatidylinositol binding  NADPH oxidase complex  NADPH oxidase complex  positive regulation of catalytic activity  regulation of respiratory burst  
Ontology : EGO-EBIprotein binding  phospholipid binding  plasma membrane  superoxide metabolic process  regulation of hydrogen peroxide metabolic process  superoxide-generating NADPH oxidase activator activity  superoxide-generating NADPH oxidase activator activity  enzyme binding  extracellular matrix disassembly  phosphatidylinositol binding  NADPH oxidase complex  NADPH oxidase complex  positive regulation of catalytic activity  regulation of respiratory burst  
NDEx NetworkNOXO1
Atlas of Cancer Signalling NetworkNOXO1
Wikipedia pathwaysNOXO1
Orthology - Evolution
OrthoDB124056
GeneTree (enSembl)ENSG00000196408
Phylogenetic Trees/Animal Genes : TreeFamNOXO1
HOGENOMQ8NFA2
Homologs : HomoloGeneNOXO1
Homology/Alignments : Family Browser (UCSC)NOXO1
Gene fusions - Rearrangements
Fusion : QuiverNOXO1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOXO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOXO1
dbVarNOXO1
ClinVarNOXO1
1000_GenomesNOXO1 
Exome Variant ServerNOXO1
ExAC (Exome Aggregation Consortium)ENSG00000196408
GNOMAD BrowserENSG00000196408
Varsome BrowserNOXO1
Genetic variants : HAPMAP124056
Genomic Variants (DGV)NOXO1 [DGVbeta]
DECIPHERNOXO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOXO1 
Mutations
ICGC Data PortalNOXO1 
TCGA Data PortalNOXO1 
Broad Tumor PortalNOXO1
OASIS PortalNOXO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOXO1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNOXO1
Mutations and Diseases : HGMDNOXO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NOXO1
DgiDB (Drug Gene Interaction Database)NOXO1
DoCM (Curated mutations)NOXO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOXO1 (select a term)
intoGenNOXO1
Cancer3DNOXO1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611256   
Orphanet
DisGeNETNOXO1
MedgenNOXO1
Genetic Testing Registry NOXO1
NextProtQ8NFA2 [Medical]
TSGene124056
GENETestsNOXO1
Target ValidationNOXO1
Huge Navigator NOXO1 [HugePedia]
snp3D : Map Gene to Disease124056
BioCentury BCIQNOXO1
ClinGenNOXO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD124056
Chemical/Pharm GKB GenePA134896072
Clinical trialNOXO1
Miscellaneous
canSAR (ICR)NOXO1 (select the gene name)
DataMed IndexNOXO1
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOXO1
EVEXNOXO1
GoPubMedNOXO1
iHOPNOXO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:58:24 CET 2019
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