NOXO1 (NADPH oxidase organizer 1)

2014-09-01  

Identity

HGNC
NOXO1
LOCATION
16p13.3
LOCUSID
124056
ALIAS
P41NOX,P41NOXA,P41NOXB,P41NOXC,SH3PXD5,SNX28

Other Information

Locus ID:

NCBI: 124056
MIM: 611256
HGNC: 19404
Ensembl: ENSG00000196408

Variants:

dbSNP: 124056
ClinVar: 124056
TCGA: ENSG00000196408
COSMIC: NOXO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196408ENST00000354249Q8NFA2
ENSG00000196408ENST00000356120Q8NFA2
ENSG00000196408ENST00000397280Q8NFA2
ENSG00000196408ENST00000566005Q8NFA2
ENSG00000196408ENST00000567471H3BN18

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate NADPH OxidasesREACTOMER-HSA-5668599

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
146176352004NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain.66
151810052004Nox3 regulation by NOXO1, p47phox, and p67phox.44
239754212014TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.40
159499042005Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3.17
204545682010Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.17
163299882006Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1.7
233221652013NOXO1 phosphorylation on serine 154 is critical for optimal NADPH oxidase 1 assembly and activation.7
293111512018Tks adaptor proteins at a glance.7
171268132007Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1).6
169115172006Expression and function of Noxo1gamma, an alternative splicing form of the NADPH oxidase organizer 1.5

Citation

Dessen P

NOXO1 (NADPH oxidase organizer 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54846/noxo1