NPAT (nuclear protein, coactivator of histone transcription)

2009-05-01  

Identity

HGNC
LOCATION
11q22.3
LOCUSID
ALIAS
E14,E14/NPAT,p220

Other Information

Locus ID:

NCBI: 4863
MIM: 601448
HGNC: 7896
Ensembl: ENSG00000149308

Variants:

dbSNP: 4863
ClinVar: 4863
TCGA: ENSG00000149308
COSMIC: NPAT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149308ENST00000278612Q14207
ENSG00000149308ENST00000527296H0YET3
ENSG00000149308ENST00000531384E9PKJ1

Expression (GTEx)

0
5
10
15
20

References

Pubmed IDYearTitleCitations
128879262003S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.172
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
146124032003The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.53
127244242003The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.47
186771002008FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy.42
179678922008Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.26
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
126655812003NPAT expression is regulated by E2F and is essential for cell cycle progression.23
174492372007Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B.23
192779822009The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types.21

Citation

Dessen P

NPAT (nuclear protein, coactivator of histone transcription)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50920/npat