NPBWR1 (neuropeptides B and W receptor 1)

2007-07-01 Affiliation

Identity

HGNC

NPBWR1

LOCATION

8q11.23

LOCUSID

2831

ALIAS

GPR7

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2831
MIM: 600730
HGNC: 4522
Ensembl: ENSG00000183729

Variants:

dbSNP: 2831
ClinVar: 2831
TCGA: ENSG00000183729
COSMIC: NPBWR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000183729	ENST00000331251	P48145
ENSG00000183729	ENST00000331251	H9NIL7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

References

Pubmed ID	Year	Title	Citations
24081945	2013	A prognostic DNA methylation signature for stage I non-small-cell lung cancer.	100
12719537	2003	Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.	37
17437806	2007	Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.	27
12118011	2002	Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.	24
12401809	2003	Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.	22
22545105	2012	A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions.	10
15797961	2005	G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.	9
15607941	2005	Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies.	7
23563248	2013	Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects.	0

Citation

Dessen P

NPBWR1 (neuropeptides B and W receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47657/npbwr1