NPFF (neuropeptide FF-amide peptide precursor)

2014-11-01  

Identity

HGNC
NPFF
LOCATION
12q13.13
LOCUSID
8620
ALIAS
FMRFAL

Other Information

Locus ID:

NCBI: 8620
MIM: 604643
HGNC: 7901
Ensembl: ENSG00000139574

Variants:

dbSNP: 8620
ClinVar: 8620
TCGA: ENSG00000139574
COSMIC: NPFF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139574ENST00000267017O15130

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Orexin and neuropeptides FF and QRFP bind to their respective receptorsREACTOMER-HSA-389397
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
178548902008Modulatory role of neuropeptide FF system in nociception and opiate analgesia.24
266605312016Gene-based pleiotropy across migraine with aura and migraine without aura patient groups.14
172244502007Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity.9
211209302011Vasopressin (VP) and neuropeptide FF (NPFF) systems in the normal and hypertensive human brainstem.5
163362162006Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line.2

Citation

Dessen P

NPFF (neuropeptide FF-amide peptide precursor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70920/npff