NPM2 (nucleophosmin/nucleoplasmin 2)

2014-11-01  

Identity

HGNC
NPM2
LOCATION
8p21.3
LOCUSID
10361
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10361
MIM: 608073
HGNC: 7930
Ensembl: ENSG00000158806

Variants:

dbSNP: 10361
ClinVar: 10361
TCGA: ENSG00000158806
COSMIC: NPM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158806ENST00000289820Q86SE8
ENSG00000158806ENST00000381530Q86SE8
ENSG00000158806ENST00000397940Q86SE8
ENSG00000158806ENST00000518119Q86SE8
ENSG00000158806ENST00000520125E5RGN1
ENSG00000158806ENST00000521157Q86SE8
ENSG00000158806ENST00000522813E5RFQ8
ENSG00000158806ENST00000615914Q86SE8
ENSG00000158806ENST00000621538Q86SE8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194911932009Genome-wide screen of promoter methylation identifies novel markers in melanoma.83
218638212011Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos.20
223627532012Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling.20
229689122012Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities.19
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.16
122096032002Increased expression of a COOH-truncated nucleophosmin resulting from alternative splicing is associated with cellular resistance to ionizing radiation in HeLa cells.12

Citation

Dessen P

NPM2 (nucleophosmin/nucleoplasmin 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70945/npm2