NPY4R (neuropeptide Y receptor Y4)

2016-12-01  

Identity

HGNC
LOCATION
10q11.22
LOCUSID
ALIAS
NPY4-R,PP1,PPYR1,Y4

Other Information

Locus ID:

NCBI: 5540
MIM: 601790
HGNC: 9329
Ensembl: ENSG00000204174

Variants:

dbSNP: 5540
ClinVar: 5540
TCGA: ENSG00000204174
COSMIC: NPY4R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204174ENST00000374312P50391
ENSG00000204174ENST00000612632P50391

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
192292532009Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population.34
119069642002Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.21
265757902016Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC.11
243754092014Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket.7
254457122015Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.7
269212182016CNV analysis and mutation screening indicate an important role for the NPY4R gene in human obesity.6
188262572008Protein phosphatase-1 is targeted to DNA polymerase delta via an interaction with the p68 subunit.3
229479432012Comparison of fragments comprising the first two helices of the human Y4 and the yeast Ste2p G-protein-coupled receptors.2
296212592018Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference.2

Citation

Dessen P

NPY4R (neuropeptide Y receptor Y4)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56655/npy4r