NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2)

2007-02-01  

Identity

HGNC
LOCATION
6p25.2
LOCUSID
ALIAS
DHQV,DIA6,NMOR2,QR2
FUSION GENES

Other Information

Locus ID:

NCBI: 4835
MIM: 160998
HGNC: 7856
Ensembl: ENSG00000124588

Variants:

dbSNP: 4835
ClinVar: 4835
TCGA: ENSG00000124588
COSMIC: NQO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124588ENST00000338130P16083
ENSG00000124588ENST00000380430P16083
ENSG00000124588ENST00000380441Q5TD07
ENSG00000124588ENST00000380454Q5TD07
ENSG00000124588ENST00000380455P16083
ENSG00000124588ENST00000380472Q5TD05
ENSG00000124588ENST00000397717Q5TD05
ENSG00000124588ENST00000426637A2A2U4
ENSG00000124588ENST00000606474U3KQG7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD21946896, 29938344
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD21946896, 29938344
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD21946896, 29938344

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
182547262008Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.25
116889922001An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2.24
116889922001An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2.24
110512612000Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia.23
159938432005Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53.20
165456792006Nuclear factor Nrf2 and antioxidant response element regulate NRH:quinone oxidoreductase 2 (NQO2) gene expression and antioxidant induction.16
185795302008Quinone reductase 2 is a catechol quinone reductase.16
196718752009Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial.16

Citation

Dessen P

NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45617/nqo2