Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NR3C1 (nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor))

Identity

Other namesGCCR
GCR
GR
GRL
HGNC (Hugo) NR3C1
LocusID (NCBI) 2908
Location 5q31.3
Location_base_pair Starts at 142657496 and ends at 142783254 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NR3C1   7978
Entrez_Gene (NCBI)NR3C1  2908  nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Cards
GeneCards (Weizmann)NR3C1
Ensembl (Hinxton)ENSG00000113580 [Gene_View]  chr5:142657496-142783254 [Contig_View]  NR3C1 [Vega]
AceView (NCBI)NR3C1
Genatlas (Paris)NR3C1
SOURCE (Stanford)NM_000176 NM_001018074 NM_001018075 NM_001018076 NM_001018077 NM_001020825 NM_001024094 NM_001204258 NM_001204259 NM_001204260 NM_001204261 NM_001204262 NM_001204263 NM_001204264 NM_001204265
Genomic and cartography
GoldenPath (UCSC)NR3C1  -  5q31.3   chr5:142657496-142783254 -  5q31.3   [Description]    (hg19-Feb_2009)
EnsemblNR3C1 - 5q31.3 [CytoView]
Mapping of homologs : NCBINR3C1 [Mapview]
OMIM138040   
Gene and transcription
Genbank (Entrez)AA737284 AB307716 AJ877166 AJ877167 AJ877168
RefSeq transcript (SRS)NM_000176 NM_001018074 NM_001018075 NM_001018076 NM_001018077 NM_001020825 NM_001024094 NM_001204258 NM_001204259 NM_001204260 NM_001204261 NM_001204262 NM_001204263 NM_001204264 NM_001204265
RefSeq transcript (Entrez)NM_000176 NM_001018074 NM_001018075 NM_001018076 NM_001018077 NM_001020825 NM_001024094 NM_001204258 NM_001204259 NM_001204260 NM_001204261 NM_001204262 NM_001204263 NM_001204264 NM_001204265
RefSeq genomic (SRS)AC_000137 NC_000005 NC_018916 NG_009062 NT_029289 NW_001838953 NW_004078025
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_009062 NT_029289 NW_001838953 NW_004078025
Consensus coding sequences : CCDS (NCBI)NR3C1
Cluster EST : UnigeneHs.122926 [ SRS ] Hs.122926 [ NCBI ]
CGAP (NCI)Hs.122926
Alternative Splicing : Fast-db (Paris)GSHG0025146
Alternative Splicing GalleryENSG00000113580
Gene ExpressionNR3C1 [ NCBI-GEO ]   NR3C1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04150 (SRS) P04150 (Uniprot)
NextProtP04150
With graphics : InterProP04150
Splice isoforms : SwissVarP04150(Swissvar)
Domaine pattern : Prosite (SRS)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (SRS)Glcrtcd_rcpt    Nucl_hormone_rcpt_ligand-bd    Nucl_hrmn_rcpt_lig-bd_core    Str_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domains : Interpro (EBI)Glcrtcd_rcpt    Nucl_hormone_rcpt_ligand-bd    Nucl_hrmn_rcpt_lig-bd_core    Str_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Related proteins : CluSTrP04150
Domain families : Pfam (SRS)GCR (PF02155)    Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (Sanger)GCR (PF02155)    Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam02155    pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
DMDM2908
Blocks (Seattle)P04150
PDB (SRS)1M2Z    1NHZ    1P93    3BQD    3CLD    3E7C    3H52    3K22    3K23    4HN5    4HN6   
PDB (PDBSum)1M2Z    1NHZ    1P93    3BQD    3CLD    3E7C    3H52    3K22    3K23    4HN5    4HN6   
PDB (IMB)1M2Z    1NHZ    1P93    3BQD    3CLD    3E7C    3H52    3K22    3K23    4HN5    4HN6   
PDB (RSDB)1M2Z    1NHZ    1P93    3BQD    3CLD    3E7C    3H52    3K22    3K23    4HN5    4HN6   
Human Protein AtlasENSG00000113580
HPRD00679
IPIIPI00022282   IPI00219946   IPI00251749   IPI01024920   IPI00604725   IPI00759700   IPI00759729   IPI01011884   IPI00978266   IPI00978393   IPI00977930   IPI00977002   IPI00976593   IPI00976066   IPI00555880   IPI00966619   
Protein Interaction databases
DIP (DOE-UCLA)P04150
IntAct (EBI)P04150
FunCoupENSG00000113580
REACTOMENR3C1
Protein Interaction Database2908
BioGRIDNR3C1
InParanoidP04150
Interologous Interaction database P04150
IntegromeDBNR3C1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NR3C1
SNP (GeneSNP Utah)NR3C1
SNP : HGBaseNR3C1
Genetic variants : HAPMAPNR3C1
Somatic Mutations in Cancer : COSMICNR3C1 
CONAN: Copy Number AnalysisNR3C1 
Mutations and Diseases : HGMDNR3C1
OMIM138040   
GENETests138040   
Disease Genetic AssociationNR3C1
Huge Navigator NR3C1 [HugePedia]  NR3C1 [HugeCancerGEM]
Genomic VariantsNR3C1  NR3C1 [DGVbeta]
ClinVarNR3C1
snp3D : Map Gene to Disease2908
General knowledge
Homologs : HomoloGeneNR3C1
Homology/Alignments : Family Browser (UCSC)NR3C1
Phylogenetic Trees/Animal Genes : TreeFamNR3C1
Chemical/Protein Interactions : CTD2908
Chemical/Pharm GKB GenePA181
Clinical trialNR3C1
Cancer Resource (Charite)ENSG00000113580
Ontology : AmiGOsequence-specific DNA binding transcription factor activity  glucocorticoid receptor activity  steroid binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrial matrix  cytosol  regulation of gluconeogenesis  transcription, DNA-dependent  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  signal transduction  glucocorticoid metabolic process  zinc ion binding  gene expression  membrane  chromatin modification  adrenal gland development  regulation of glucocorticoid biosynthetic process  positive regulation of neuron apoptotic process  sequence-specific DNA binding  protein dimerization activity  mammary gland duct morphogenesis  
Ontology : EGO-EBIsequence-specific DNA binding transcription factor activity  glucocorticoid receptor activity  steroid binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrial matrix  cytosol  regulation of gluconeogenesis  transcription, DNA-dependent  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  signal transduction  glucocorticoid metabolic process  zinc ion binding  gene expression  membrane  chromatin modification  adrenal gland development  regulation of glucocorticoid biosynthetic process  positive regulation of neuron apoptotic process  sequence-specific DNA binding  protein dimerization activity  mammary gland duct morphogenesis  
Pathways : BIOCARTAChromatin Remodeling by hSWI/SNF ATP-dependent Complexes [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]    Visceral Fat Deposits and the Metabolic Syndrome [Genes]    Corticosteroids and cardioprotection [Genes]   
Pathways : KEGGNeuroactive ligand-receptor interaction
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneNR3C1
iHOPNR3C1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:35:39 CEST 2013
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