NR4A2 (nuclear receptor subfamily 4 group A member 2)

2007-02-01 Affiliation

Identity

HGNC

NR4A2

LOCATION

2q24.1

LOCUSID

4929

ALIAS

HZF-3,NOT,NURR1,RNR1,TINUR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4929
MIM: 601828
HGNC: 7981
Ensembl: ENSG00000153234

Variants:

dbSNP: 4929
ClinVar: 4929
TCGA: ENSG00000153234
COSMIC: NR4A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000153234	ENST00000339562	P43354
ENSG00000153234	ENST00000339562	F1D8N6
ENSG00000153234	ENST00000406048	H7BZ00
ENSG00000153234	ENST00000409108	F8W6I3
ENSG00000153234	ENST00000409572	P43354
ENSG00000153234	ENST00000409572	F1D8N6
ENSG00000153234	ENST00000417764	E9PBQ4
ENSG00000153234	ENST00000417972	E9PBQ4
ENSG00000153234	ENST00000421709	C9JWQ1
ENSG00000153234	ENST00000424077	C9IYM5
ENSG00000153234	ENST00000426264	P43354
ENSG00000153234	ENST00000429376	C9J8W4

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Nuclear Receptor transcription pathway	REACTOME	R-HSA-383280
Aldosterone synthesis and secretion	KEGG	hsa04925
Aldosterone synthesis and secretion	KEGG	ko04925

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18583979	2008	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	395
12774125	2003	Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors.	153
20016108	2009	Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons.	125
12496759	2003	Mutations in NR4A2 associated with familial Parkinson disease.	113
12496759	2003	Mutations in NR4A2 associated with familial Parkinson disease.	113
15964844	2005	Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli.	87
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16873729	2006	Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses.	81
22764233	2012	Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.	71
18937842	2008	The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.	63

Citation

Dessen P

NR4A2 (nuclear receptor subfamily 4 group A member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46489/nr4a2