NR6A1 (nuclear receptor subfamily 6 group A member 1)

2007-02-01 Affiliation

Identity

HGNC

NR6A1

LOCATION

9q33.3

LOCUSID

2649

ALIAS

CT150,GCNF,GCNF1,NR61,RTR,hGCNF,hRTR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2649
MIM: 602778
HGNC: 7985
Ensembl: ENSG00000148200

Variants:

dbSNP: 2649
ClinVar: 2649
TCGA: ENSG00000148200
COSMIC: NR6A1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000148200	ENST00000344523	Q15406
ENSG00000148200	ENST00000373584	Q15406
ENSG00000148200	ENST00000373584	F1DAM1
ENSG00000148200	ENST00000416460	Q15406
ENSG00000148200	ENST00000475178	C9JDI9
ENSG00000148200	ENST00000487099	Q15406
ENSG00000148200	ENST00000487099	F1D8S0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Nuclear Receptor transcription pathway	REACTOME	R-HSA-383280
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of pluripotent stem cells	REACTOME	R-HSA-452723
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	REACTOME	R-HSA-2892247

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
12080054	2002	RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor.	18
20583170	2010	Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.	8
21056546	2010	Transcriptional regulation of the hypocretin/orexin gene by NR6A1.	8
26769970	2016	Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells.	6
11969338	2002	Characterization of the expression of the retinoid-related, testis-associated receptor (RTR) in trophoblasts.	4
15456763	2004	Germ cell nuclear factor relieves cAMP-response element modulator tau-mediated activation of the testis-specific promoter of human mitochondrial glycerol-3-phosphate dehydrogenase.	2
23495137	2013	Epigenetic reprogramming of the germ cell nuclear factor gene is required for proper differentiation of induced pluripotent cells.	0
23532770	2013	Expression screening of cancer/testis genes in prostate cancer identifies NR6A1 as a novel marker of disease progression and aggressiveness.	0
29057499	2018	GCNF regulates OCT4 expression through its interactions with nuclear receptor binding elements in NCCIT cells.	0

Citation

Dessen P

NR6A1 (nuclear receptor subfamily 6 group A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45696/nr6a1