Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NR6A1 (nuclear receptor subfamily 6 group A member 1)

Identity

Alias_namesGCNF
nuclear receptor subfamily 6, group A, member 1
Alias_symbol (synonym)GCNF1
RTR
CT150
Other aliasNR61
hGCNF
hRTR
HGNC (Hugo) NR6A1
LocusID (NCBI) 2649
Atlas_Id 45696
Location 9q33.3  [Link to chromosome band 9q33]
Location_base_pair Starts at 124517275 and ends at 124771310 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD74 (5q32) / NR6A1 (9q33.3)NR6A1 (9q33.3) / ATF3 (1q32.3)NR6A1 (9q33.3) / GOLGA1 (9q33.3)
NR6A1 (9q33.3) / OBP2B (9q34.2)NR6A1 (9q33.3) / PSMB7 (9q33.3)NR6A1 (9q33.3) / TRHDE (12q21.1)
SEC23A (14q21.1) / NR6A1 (9q33.3)NR6A1 9q33.3 / GOLGA1 9q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;9)(q33;q34) NR6A1/OBP2B

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  NR5A1/NR6A1 (9q33)
NR6A1/GOLGA1 (9q33)
t(9;12)(q33;q21) NR6A1/TRHDE

External links

Nomenclature
HGNC (Hugo)NR6A1   7985
Cards
Entrez_Gene (NCBI)NR6A1  2649  nuclear receptor subfamily 6 group A member 1
AliasesCT150; GCNF; GCNF1; NR61; 
RTR; hGCNF; hRTR
GeneCards (Weizmann)NR6A1
Ensembl hg19 (Hinxton)ENSG00000148200 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148200 [Gene_View]  ENSG00000148200 [Sequence]  chr9:124517275-124771310 [Contig_View]  NR6A1 [Vega]
ICGC DataPortalENSG00000148200
TCGA cBioPortalNR6A1
AceView (NCBI)NR6A1
Genatlas (Paris)NR6A1
WikiGenes2649
SOURCE (Princeton)NR6A1
Genetics Home Reference (NIH)NR6A1
Genomic and cartography
GoldenPath hg38 (UCSC)NR6A1  -     chr9:124517275-124771310 -  9q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NR6A1  -     9q33.3   [Description]    (hg19-Feb_2009)
GoldenPathNR6A1 - 9q33.3 [CytoView hg19]  NR6A1 - 9q33.3 [CytoView hg38]
ImmunoBaseENSG00000148200
Mapping of homologs : NCBINR6A1 [Mapview hg19]  NR6A1 [Mapview hg38]
OMIM602778   
Gene and transcription
Genbank (Entrez)AA467752 AF004291 BC027988 BC030600 BC042395
RefSeq transcript (Entrez)NM_001278546 NM_001489 NM_033334 NM_033335
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NR6A1
Cluster EST : UnigeneHs.586460 [ NCBI ]
CGAP (NCI)Hs.586460
Alternative Splicing GalleryENSG00000148200
Gene ExpressionNR6A1 [ NCBI-GEO ]   NR6A1 [ EBI - ARRAY_EXPRESS ]   NR6A1 [ SEEK ]   NR6A1 [ MEM ]
Gene Expression Viewer (FireBrowse)NR6A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2649
GTEX Portal (Tissue expression)NR6A1
Human Protein AtlasENSG00000148200-NR6A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15406   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15406  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15406
Splice isoforms : SwissVarQ15406
PhosPhoSitePlusQ15406
Domaine pattern : Prosite (Expaxy)NR_LBD (PS51843)    NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)NHR_like_dom_sf    Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)NR6A1
DMDM Disease mutations2649
Blocks (Seattle)NR6A1
SuperfamilyQ15406
Human Protein Atlas [tissue]ENSG00000148200-NR6A1 [tissue]
Peptide AtlasQ15406
HPRD04147
IPIIPI00017258   IPI00220041   IPI00413606   IPI00743885   IPI00848326   
Protein Interaction databases
DIP (DOE-UCLA)Q15406
IntAct (EBI)Q15406
FunCoupENSG00000148200
BioGRIDNR6A1
STRING (EMBL)NR6A1
ZODIACNR6A1
Ontologies - Pathways
QuickGOQ15406
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  steroid hormone receptor activity  nuclear receptor activity  nucleus  nucleoplasm  transcription factor complex  transcription factor complex  transcription initiation from RNA polymerase II promoter  gamete generation  zinc ion binding  intracellular receptor signaling pathway  protein homodimerization activity  steroid hormone mediated signaling pathway  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  steroid hormone receptor activity  nuclear receptor activity  nucleus  nucleoplasm  transcription factor complex  transcription factor complex  transcription initiation from RNA polymerase II promoter  gamete generation  zinc ion binding  intracellular receptor signaling pathway  protein homodimerization activity  steroid hormone mediated signaling pathway  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  
NDEx NetworkNR6A1
Atlas of Cancer Signalling NetworkNR6A1
Wikipedia pathwaysNR6A1
Orthology - Evolution
OrthoDB2649
GeneTree (enSembl)ENSG00000148200
Phylogenetic Trees/Animal Genes : TreeFamNR6A1
HOGENOMQ15406
Homologs : HomoloGeneNR6A1
Homology/Alignments : Family Browser (UCSC)NR6A1
Gene fusions - Rearrangements
Fusion : MitelmanNR6A1/GOLGA1 [9q33.3/9q33.3]  
Fusion : MitelmanNR6A1/OBP2B [9q33.3/9q34.2]  [t(9;9)(q33;q34)]  
Fusion : MitelmanNR6A1/TRHDE [9q33.3/12q21.1]  [t(9;12)(q33;q21)]  
Fusion PortalNR6A1 9q33.3 GOLGA1 9q33.3 SKCM
Fusion : QuiverNR6A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNR6A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NR6A1
dbVarNR6A1
ClinVarNR6A1
1000_GenomesNR6A1 
Exome Variant ServerNR6A1
ExAC (Exome Aggregation Consortium)ENSG00000148200
GNOMAD BrowserENSG00000148200
Varsome BrowserNR6A1
Genetic variants : HAPMAP2649
Genomic Variants (DGV)NR6A1 [DGVbeta]
DECIPHERNR6A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNR6A1 
Mutations
ICGC Data PortalNR6A1 
TCGA Data PortalNR6A1 
Broad Tumor PortalNR6A1
OASIS PortalNR6A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNR6A1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNR6A1
Mutations and Diseases : HGMDNR6A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NR6A1
DgiDB (Drug Gene Interaction Database)NR6A1
DoCM (Curated mutations)NR6A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NR6A1 (select a term)
intoGenNR6A1
Cancer3DNR6A1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602778   
Orphanet
DisGeNETNR6A1
MedgenNR6A1
Genetic Testing Registry NR6A1
NextProtQ15406 [Medical]
TSGene2649
GENETestsNR6A1
Target ValidationNR6A1
Huge Navigator NR6A1 [HugePedia]
snp3D : Map Gene to Disease2649
BioCentury BCIQNR6A1
ClinGenNR6A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2649
Chemical/Pharm GKB GenePA31766
Clinical trialNR6A1
Miscellaneous
canSAR (ICR)NR6A1 (select the gene name)
DataMed IndexNR6A1
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNR6A1
EVEXNR6A1
GoPubMedNR6A1
iHOPNR6A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:58:36 CET 2019
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