NRBP1 (nuclear receptor binding protein 1)

2007-02-01  

Identity

HGNC
LOCATION
2p23.3
LOCUSID
ALIAS
BCON3,MADM,MUDPNP,NRBP
FUSION GENES

Other Information

Locus ID:

NCBI: 29959
MIM: 606010
HGNC: 7993
Ensembl: ENSG00000115216

Variants:

dbSNP: 29959
ClinVar: 29959
TCGA: ENSG00000115216
COSMIC: NRBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115216ENST00000233557Q9UHY1
ENSG00000115216ENST00000356442C9JDW7
ENSG00000115216ENST00000379852Q9UHY1
ENSG00000115216ENST00000379863F8W6G1
ENSG00000115216ENST00000419281C9JHZ6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
225108802012Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.17
150843972004The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure.13
121769952002MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.12
224739232012High NRBP1 expression in prostate cancer is linked with poor clinical outcomes and increased cancer cell growth.9
119566492002Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain.6
295679972018Nuclear receptor binding protein 1 correlates with better prognosis and induces caspase-dependent intrinsic apoptosis through the JNK signalling pathway in colorectal cancer.5
170527102006Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity.4
243722402013Design, virtual screening and docking study of novel NS3 inhibitors by targeting protein-protein interacting sites of dengue virus - a novel approach.2
289323192017DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding.2
249100132014Insight into structural organization and protein-protein interaction of non structural 3 (NS3) proteins from dengue serotypes.1

Citation

Dessen P

NRBP1 (nuclear receptor binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45720/nrbp1