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NRDC (nardilysin convertase)

Identity

Alias (NCBI)NRD1
hNRD1
hNRD2
HGNC (Hugo) NRDC
HGNC Alias symbhNRD1
hNRD2
HGNC Alias nameN-arginine dibasic convertase
HGNC Previous nameNRD1
HGNC Previous namenardilysin (N-arginine dibasic convertase)
LocusID (NCBI) 4898
Atlas_Id 41579
Location 1p32.3  [Link to chromosome band 1p32]
Location_base_pair Starts at 51789194 and ends at 51878937 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG14 (1p21.3) / NRDC (1p32.3)KAT6B (10q22.2) / NRDC (1p32.3)NRDC (1p32.3) / KCNK9 (8q24.3)
NRDC (1p32.3) / USP24 (1p32.3)OPCML (11q25) / NRDC (1p32.3)PNRC1 (6q15) / NRDC (1p32.3)
TMEM2 (9q21.13) / NRDC (1p32.3)TMEM63A (1q42.12) / NRDC (1p32.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)NRDC   7995
Cards
Entrez_Gene (NCBI)NRDC  4898  nardilysin convertase
AliasesNRD1; hNRD1; hNRD2
GeneCards (Weizmann)NRDC
Ensembl hg19 (Hinxton)ENSG00000078618 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000078618 [Gene_View]  ENSG00000078618 [Sequence]  chr1:51789194-51878937 [Contig_View]  NRDC [Vega]
ICGC DataPortalENSG00000078618
TCGA cBioPortalNRDC
AceView (NCBI)NRDC
Genatlas (Paris)NRDC
WikiGenes4898
SOURCE (Princeton)NRDC
Genetics Home Reference (NIH)NRDC
Genomic and cartography
GoldenPath hg38 (UCSC)NRDC  -     chr1:51789194-51878937 -  1p32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRDC  -     1p32.3   [Description]    (hg19-Feb_2009)
GoldenPathNRDC - 1p32.3 [CytoView hg19]  NRDC - 1p32.3 [CytoView hg38]
ImmunoBaseENSG00000078618
genome Data Viewer NCBINRDC [Mapview hg19]  
OMIM602651   
Gene and transcription
Genbank (Entrez)AK055516 AK299271 AK302616 AK311631 AK312318
RefSeq transcript (Entrez)NM_001101662 NM_001242361 NM_002525
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NRDC
Alternative Splicing GalleryENSG00000078618
Gene ExpressionNRDC [ NCBI-GEO ]   NRDC [ EBI - ARRAY_EXPRESS ]   NRDC [ SEEK ]   NRDC [ MEM ]
Gene Expression Viewer (FireBrowse)NRDC [ Firebrowse - Broad ]
GenevisibleExpression of NRDC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4898
GTEX Portal (Tissue expression)NRDC
Human Protein AtlasENSG00000078618-NRDC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43847   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43847  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43847
Splice isoforms : SwissVarO43847
Catalytic activity : Enzyme3.4.24.61 [ Enzyme-Expasy ]   3.4.24.613.4.24.61 [ IntEnz-EBI ]   3.4.24.61 [ BRENDA ]   3.4.24.61 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO43847
Domaine pattern : Prosite (Expaxy)INSULINASE (PS00143)   
Domains : Interpro (EBI)Metalloenz_LuxS/M16    Pept_M16_N    Pept_M16_Zn_BS    Peptidase_M16_C    Peptidase_M16_M   
Domain families : Pfam (Sanger)Peptidase_M16 (PF00675)    Peptidase_M16_C (PF05193)    Peptidase_M16_M (PF16187)   
Domain families : Pfam (NCBI)pfam00675    pfam05193    pfam16187   
Conserved Domain (NCBI)NRDC
DMDM Disease mutations4898
Blocks (Seattle)NRDC
SuperfamilyO43847
Human Protein Atlas [tissue]ENSG00000078618-NRDC [tissue]
Peptide AtlasO43847
HPRD04036
IPIIPI00889668   IPI00513946   IPI01012543   IPI01011457   IPI01010152   IPI00478723   IPI00243221   
Protein Interaction databases
DIP (DOE-UCLA)O43847
IntAct (EBI)O43847
FunCoupENSG00000078618
BioGRIDNRDC
STRING (EMBL)NRDC
ZODIACNRDC
Ontologies - Pathways
QuickGOO43847
Ontology : AmiGOmetalloendopeptidase activity  protein binding  mitochondrion  cytosol  cell surface  metal ion binding  epidermal growth factor binding  positive regulation of membrane protein ectodomain proteolysis  regulation of endopeptidase activity  negative regulation of cold-induced thermogenesis  
Ontology : EGO-EBImetalloendopeptidase activity  protein binding  mitochondrion  cytosol  cell surface  metal ion binding  epidermal growth factor binding  positive regulation of membrane protein ectodomain proteolysis  regulation of endopeptidase activity  negative regulation of cold-induced thermogenesis  
NDEx NetworkNRDC
Atlas of Cancer Signalling NetworkNRDC
Wikipedia pathwaysNRDC
Orthology - Evolution
OrthoDB4898
GeneTree (enSembl)ENSG00000078618
Phylogenetic Trees/Animal Genes : TreeFamNRDC
HOGENOMO43847
Homologs : HomoloGeneNRDC
Homology/Alignments : Family Browser (UCSC)NRDC
Gene fusions - Rearrangements
Fusion : QuiverNRDC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRDC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRDC
dbVarNRDC
ClinVarNRDC
1000_GenomesNRDC 
Exome Variant ServerNRDC
GNOMAD BrowserENSG00000078618
Varsome BrowserNRDC
Genetic variants : HAPMAP4898
Genomic Variants (DGV)NRDC [DGVbeta]
DECIPHERNRDC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRDC 
Mutations
ICGC Data PortalNRDC 
TCGA Data PortalNRDC 
Broad Tumor PortalNRDC
OASIS PortalNRDC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRDC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNRDC
Mutations and Diseases : HGMDNRDC
BioMutasearch NRDC
DgiDB (Drug Gene Interaction Database)NRDC
DoCM (Curated mutations)NRDC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRDC (select a term)
intoGenNRDC
Cancer3DNRDC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602651   
Orphanet
DisGeNETNRDC
MedgenNRDC
Genetic Testing Registry NRDC
NextProtO43847 [Medical]
TSGene4898
GENETestsNRDC
Target ValidationNRDC
Huge Navigator NRDC [HugePedia]
snp3D : Map Gene to Disease4898
BioCentury BCIQNRDC
ClinGenNRDC
Clinical trials, drugs, therapy
Protein Interactions : CTD4898
Pharm GKB GenePA31774
Clinical trialNRDC
Miscellaneous
canSAR (ICR)NRDC (select the gene name)
HarmonizomeNRDC
DataMed IndexNRDC
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRDC
EVEXNRDC
GoPubMedNRDC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:27:43 CEST 2020
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