NRG1 (neuregulin 1)

2007-02-01  

Identity

HGNC
NRG1
LOCATION
8p12
LOCUSID
3084
ALIAS
ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,MSTP131,NDF,NRG1-IT2,SMDF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3084
MIM: 142445
HGNC: 7997
Ensembl: ENSG00000157168

Variants:

dbSNP: 3084
ClinVar: 3084
TCGA: ENSG00000157168
COSMIC: NRG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157168ENST00000287842Q02297
ENSG00000157168ENST00000356819Q02297
ENSG00000157168ENST00000405005Q02297
ENSG00000157168ENST00000518084E5RHQ1
ENSG00000157168ENST00000518206H0YCP0
ENSG00000157168ENST00000519240E5RIG8
ENSG00000157168ENST00000519301Q02297
ENSG00000157168ENST00000520407Q02297
ENSG00000157168ENST00000520502Q02297
ENSG00000157168ENST00000521670Q02297
ENSG00000157168ENST00000522402E5RHP6
ENSG00000157168ENST00000523041H0YDC2
ENSG00000157168ENST00000523079Q02297
ENSG00000157168ENST00000523534H0YBA3
ENSG00000157168ENST00000539990F6RJN6
ENSG00000157168ENST00000614767A0A087X0X9
ENSG00000157168ENST00000650819A0A494C1B5
ENSG00000157168ENST00000650856A0A494BZT4
ENSG00000157168ENST00000650866A0A494C1F5
ENSG00000157168ENST00000650919Q02297
ENSG00000157168ENST00000650919A0A024QY88
ENSG00000157168ENST00000650967A0A494C114
ENSG00000157168ENST00000650980A0A494C0K4
ENSG00000157168ENST00000651149A0A494C054
ENSG00000157168ENST00000651333A0A494C0L9
ENSG00000157168ENST00000651335A0A494C1G2
ENSG00000157168ENST00000651696A0A494C0T5
ENSG00000157168ENST00000652588A0A494C043
ENSG00000157168ENST00000652592A0A494C0Q4
ENSG00000157168ENST00000652698A0A494C1F8

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
ErbB signaling pathwayKEGGhsa04012
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
PI3K/AKT Signaling in CancerREACTOMER-HSA-2219528
Constitutive Signaling by Aberrant PI3K in CancerREACTOMER-HSA-2219530
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Negative regulation of the PI3K/AKT networkREACTOMER-HSA-199418
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
RAF/MAP kinase cascadeREACTOMER-HSA-5673001
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Interleukin receptor SHC signalingREACTOMER-HSA-912526
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GRB2 events in EGFR signalingREACTOMER-HSA-179812
SHC1 events in EGFR signalingREACTOMER-HSA-180336
GAB1 signalosomeREACTOMER-HSA-180292
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
SOS-mediated signallingREACTOMER-HSA-112412
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Signaling by SCF-KITREACTOMER-HSA-1433557
Signaling by ERBB2REACTOMER-HSA-1227986
SHC1 events in ERBB2 signalingREACTOMER-HSA-1250196
GRB2 events in ERBB2 signalingREACTOMER-HSA-1963640
PI3K events in ERBB2 signalingREACTOMER-HSA-1963642
GRB7 events in ERBB2 signalingREACTOMER-HSA-1306955
Downregulation of ERBB2:ERBB3 signalingREACTOMER-HSA-1358803
Signaling by ERBB4REACTOMER-HSA-1236394
SHC1 events in ERBB4 signalingREACTOMER-HSA-1250347
PI3K events in ERBB4 signalingREACTOMER-HSA-1250342
Nuclear signaling by ERBB4REACTOMER-HSA-1251985
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Signaling by LeptinREACTOMER-HSA-2586552
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingREACTOMER-HSA-6811558
ERBB2 Regulates Cell MotilityREACTOMER-HSA-6785631
ERBB2 Activates PTK6 SignalingREACTOMER-HSA-8847993
Signaling by PTK6REACTOMER-HSA-8848021
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521
RET signalingREACTOMER-HSA-8853659
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10040cetuximabChemicalPathwayassociated
PA162373091panitumumabChemicalPathwayassociated
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
381757742024Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma.0
382247922024Neuregulin 1 as a potential biomarker for disease progression in moyamoya disease: A case-control study in Chinese population.0
382625642024Identification and validation of CRLF1 and NRG1 as immune-related signatures in hypertrophic scar.0
383319052024Diagnostic potential of NRG1 in benign nerve sheath tumors and its influence on the PI3K-Akt signaling and tumor immunity.0
383554482024The involvement of Neuregulin-1 in the process of facial nerve injury repair through the utilization of dental pulp stem cells.0
383695202024Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer.2
386740542024Myeloid Cell-Derived IL-1 Signaling Damps Neuregulin-1 from Fibroblasts to Suppress Colitis-Induced Early Repair of the Intestinal Epithelium.0
381757742024Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma.0
382247922024Neuregulin 1 as a potential biomarker for disease progression in moyamoya disease: A case-control study in Chinese population.0
382625642024Identification and validation of CRLF1 and NRG1 as immune-related signatures in hypertrophic scar.0
383319052024Diagnostic potential of NRG1 in benign nerve sheath tumors and its influence on the PI3K-Akt signaling and tumor immunity.0
383554482024The involvement of Neuregulin-1 in the process of facial nerve injury repair through the utilization of dental pulp stem cells.0
383695202024Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer.2
386740542024Myeloid Cell-Derived IL-1 Signaling Damps Neuregulin-1 from Fibroblasts to Suppress Colitis-Induced Early Repair of the Intestinal Epithelium.0
364733962023Neuregulin-1 attenuates hemolysis- and ischemia induced-cerebrovascular inflammation associated with sickle cell disease.1

Citation

Dessen P

NRG1 (neuregulin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45743/nrg1