NRN1 (neuritin 1)

2003-05-01  

Identity

HGNC
NRN1
LOCATION
6p25.1
LOCUSID
51299
ALIAS
NRN,dJ380B8.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51299
MIM: 607409
HGNC: 17972
Ensembl: ENSG00000124785

Variants:

dbSNP: 51299
ClinVar: 51299
TCGA: ENSG00000124785
COSMIC: NRN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124785ENST00000244766Q9NPD7
ENSG00000124785ENST00000616243Q9NPD7
ENSG00000124785ENST00000622188A0A087WWT2

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

References

Pubmed IDYearTitleCitations
216527742011Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits.88
167231262006Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer.36
182650092008cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival.22
273070452016Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.11
250367382014MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression.10
195690752010Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia.9
204052462011Neuritin expression and its relation with proliferation, apoptosis, and angiogenesis in human astrocytoma.9
251018292014Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.7
262083912015Effects of neuritin on the migration, senescence and proliferation of human bone marrow mesenchymal stem cells.5
267004052016Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning.4

Citation

Dessen P

NRN1 (neuritin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41581/nrn1