NRP2 (neuropilin 2)

2004-02-01  

Identity

HGNC
LOCATION
2q33.3
LOCUSID
ALIAS
NP2,NPN2,PRO2714,VEGF165R2
FUSION GENES

Other Information

Locus ID:

NCBI: 8828
MIM: 602070
HGNC: 8005
Ensembl: ENSG00000118257

Variants:

dbSNP: 8828
ClinVar: 8828
TCGA: ENSG00000118257
COSMIC: NRP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118257ENST00000272849O60462
ENSG00000118257ENST00000357118O60462
ENSG00000118257ENST00000357785O60462
ENSG00000118257ENST00000360409O60462
ENSG00000118257ENST00000412873O60462
ENSG00000118257ENST00000417189O60462
ENSG00000118257ENST00000450507C9JH98

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
Neurophilin interactions with VEGF and VEGFRREACTOMER-HSA-194306
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
NrCAM interactionsREACTOMER-HSA-447038

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPKPD18451141
PA449212daunorubicinChemicalClinicalAnnotationassociatedPKPD18451141

References

Pubmed IDYearTitleCitations
377879672024Neuropilin-2 acts a critical determinant for epithelial-to-mesenchymal transition and aggressive behaviors of human head and neck cancer.1
378780352024Expression of placental growth factor, neuropilin-1, and neuropilin-2 in primary pterygium tissue.0
379427012024Association of plasma NRP2 and VEGF-C levels with prostate cancer disease severity.0
377879672024Neuropilin-2 acts a critical determinant for epithelial-to-mesenchymal transition and aggressive behaviors of human head and neck cancer.1
378780352024Expression of placental growth factor, neuropilin-1, and neuropilin-2 in primary pterygium tissue.0
379427012024Association of plasma NRP2 and VEGF-C levels with prostate cancer disease severity.0
361942492023Proteomic analysis of diabetes genetic risk scores identifies complement C2 and neuropilin-2 as predictors of type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) Study.2
370250722023Adipose-derived mesenchymal stem cells-sourced exosomal microRNA-7846-3p suppresses proliferation and pro-angiogenic role of keloid fibroblasts by suppressing neuropilin 2.3
375151852023Tumor Necrosis Factor and Interleukin-1β Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation.1
378130992023CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the miR-1287-5p-Mediated NRP2 Expression Elevation.0
361942492023Proteomic analysis of diabetes genetic risk scores identifies complement C2 and neuropilin-2 as predictors of type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) Study.2
370250722023Adipose-derived mesenchymal stem cells-sourced exosomal microRNA-7846-3p suppresses proliferation and pro-angiogenic role of keloid fibroblasts by suppressing neuropilin 2.3
375151852023Tumor Necrosis Factor and Interleukin-1β Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation.1
378130992023CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the miR-1287-5p-Mediated NRP2 Expression Elevation.0
350289752022NRP2 promotes atherosclerosis by upregulating PARP1 expression and enhancing low shear stress-induced endothelial cell apoptosis.9

Citation

Dessen P

NRP2 (neuropilin 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/41583/nrp2