NRROS (negative regulator of reactive oxygen species)

2018-11-01  

Identity

HGNC
LOCATION
3q29
LOCUSID
ALIAS
ELLP3030,GARPL1,LRRC33,SENEBAC,UNQ3030
FUSION GENES

Other Information

Locus ID:

NCBI: 375387
MIM: 615322
HGNC: 24613
Ensembl: ENSG00000174004

Variants:

dbSNP: 375387
ClinVar: 375387
TCGA: ENSG00000174004
COSMIC: NRROS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174004ENST00000328557Q86YC3

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
316002002019LRRC33 is a novel binding and potential regulating protein of TGF-β1 function in human acute myeloid leukemia cells.2
316443092019Association Study Reveals One Susceptibility Locus with Vitiligo in the Chinese Han Population.1
235452602013Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-κB activation.0
245505252014Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors.0
321970752020Bi-allelic LoF NRROS Variants Impairing Active TGF-β1 Delivery Cause a Severe Infantile-Onset Neurodegenerative Condition with Intracranial Calcification.0

Citation

Dessen P

NRROS (negative regulator of reactive oxygen species)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57651/nrros