NRXN3 (neurexin 3)

2012-06-01 Affiliation

Identity

HGNC

NRXN3

LOCATION

14q31.1

LOCUSID

9369

ALIAS

C14orf60

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9369
MIM: 600567
HGNC: 8010
Ensembl: ENSG00000021645

Variants:

dbSNP: 9369
ClinVar: 9369
TCGA: ENSG00000021645
COSMIC: NRXN3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000021645	ENST00000281127	Q9HDB5
ENSG00000021645	ENST00000335750	A0A0A0MR89
ENSG00000021645	ENST00000428277	Q9HDB5
ENSG00000021645	ENST00000553363	H0YJL2
ENSG00000021645	ENST00000553631	G3V4R9
ENSG00000021645	ENST00000554719	Q9Y4C0
ENSG00000021645	ENST00000554738	Q9Y4C0
ENSG00000021645	ENST00000555387	A0A0C4DGK4
ENSG00000021645	ENST00000557081	G3V247
ENSG00000021645	ENST00000557594	Q9HDB5
ENSG00000021645	ENST00000634499	A0A0U1RQC5
ENSG00000021645	ENST00000635466	A0A0U1RRJ0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Neuronal System	REACTOME	R-HSA-112316
Protein-protein interactions at synapses	REACTOME	R-HSA-6794362
Interactions of neurexins and neuroligins at synapses	REACTOME	R-HSA-6794361

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18519826	2008	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	130
19557197	2009	NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.	109
22209245	2012	Rare deletions at the neurexin 3 locus in autism spectrum disorder.	80
8163501	1994	Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.	62
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
9856994	1998	Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.	49
17804423	2007	Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms.	48
17804423	2007	Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms.	48
20724581	2010	Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.	47
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34

Citation

Dessen P

NRXN3 (neurexin 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52734/nrxn3