NSA2 (NSA2 ribosome biogenesis factor)

2016-10-01  

Identity

HGNC
NSA2
LOCATION
5q13.3
LOCUSID
10412
ALIAS
CDK105,HCL-G1,HCLG1,HUSSY-29,HUSSY29,TINP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10412
MIM: 612497
HGNC: 30728
Ensembl: ENSG00000164346

Variants:

dbSNP: 10412
ClinVar: 10412
TCGA: ENSG00000164346
COSMIC: NSA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164346ENST00000296802A0A0A0MQZ6
ENSG00000164346ENST00000515524H0YAI9
ENSG00000164346ENST00000610426O95478
ENSG00000164346ENST00000610426Q5J7U2

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
168612252006Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs.30
199326872010NSA2, a novel nucleolus protein regulates cell proliferation and cell cycle.9
232201732013Nop-7-associated 2 (NSA2), a candidate gene for diabetic nephropathy, is involved in the TGFβ1 pathway.3
239122752013A novel human TINP1 gene promotes cell proliferation through inhibition of p53 and p21 expression.3
220952362012Elevated levels of renal and circulating Nop-7-associated 2 (NSA2) in rat and mouse models of diabetes, in mesangial cells in vitro and in patients with diabetic nephropathy.2
302437192018Nop-7-associated 2 (NSA2) is required for ribosome biogenesis and protein synthesis.1

Citation

Dessen P

NSA2 (NSA2 ribosome biogenesis factor)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56579/nsa2