NSMCE1 (NSE1 homolog, SMC5-SMC6 complex component)

2008-07-01  

Identity

HGNC
NSMCE1
LOCATION
16p12.1
LOCUSID
197370
ALIAS
NSE1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 197370
MIM: 617263
HGNC: 29897
Ensembl: ENSG00000169189

Variants:

dbSNP: 197370
ClinVar: 197370
TCGA: ENSG00000169189
COSMIC: NSMCE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169189ENST00000361439Q8WV22
ENSG00000169189ENST00000562039H3BV05
ENSG00000169189ENST00000563273I3L1I3
ENSG00000169189ENST00000563900H3BSL0
ENSG00000169189ENST00000564342H3BR73
ENSG00000169189ENST00000566087H3BR31
ENSG00000169189ENST00000567710H3BN81
ENSG00000169189ENST00000569236H3BR31

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
186675312008Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.31

Citation

Dessen P

NSMCE1 (NSE1 homolog, SMC5-SMC6 complex component)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50241/nsmce1