NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1)

2016-03-01  

Identity

HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
AD-003,C9orf32,HOMT1A,METTL11A,NRMT,NRMT1,NTM1A

Other Information

Locus ID:

NCBI: 28989
MIM: 613560
HGNC: 23373
Ensembl: ENSG00000148335

Variants:

dbSNP: 28989
ClinVar: 28989
TCGA: ENSG00000148335
COSMIC: NTMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148335ENST00000372480Q9BV86
ENSG00000148335ENST00000372480A0A024R8E4
ENSG00000148335ENST00000372481Q9BV86
ENSG00000148335ENST00000372483Q9BV86
ENSG00000148335ENST00000372483A0A024R8E4
ENSG00000148335ENST00000372486Q9BV86
ENSG00000148335ENST00000372486A0A024R8E4
ENSG00000148335ENST00000459968S4R3J7
ENSG00000148335ENST00000481189S4R344
ENSG00000148335ENST00000482347S4R338
ENSG00000148335ENST00000611055Q9BV86
ENSG00000148335ENST00000611055A0A024R8E4
ENSG00000148335ENST00000613644Q9BV86
ENSG00000148335ENST00000613644A0A024R8E4
ENSG00000148335ENST00000617943S4R338

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206684492010NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.48
227698512012Substrate specificity of mammalian N-terminal α-amino methyltransferase NRMT.26
282665062017α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere.23
258432352015NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging.17
240903522013NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.16
257715392015Kinetic mechanism of protein N-terminal methyltransferase 1.13
265431592015Molecular basis for histone N-terminal methylation by NRMT1.11
285565662017Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.7
301519282018The N-terminal methyltransferase homologs NRMT1 and NRMT2 exhibit novel regulation of activity through heterotrimer formation.0

Citation

Dessen P

NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-03-01

Online version: http://atlasgeneticsoncology.org/gene/55667/ntmt1