NTN4 (netrin 4)

2007-08-01  

Identity

HGNC
LOCATION
12q22
LOCUSID
ALIAS
PRO3091
FUSION GENES

Other Information

Locus ID:

NCBI: 59277
MIM: 610401
HGNC: 13658
Ensembl: ENSG00000074527

Variants:

dbSNP: 59277
ClinVar: 59277
TCGA: ENSG00000074527
COSMIC: NTN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074527ENST00000343702Q9HB63
ENSG00000074527ENST00000344911Q9HB63
ENSG00000074527ENST00000538383Q9HB63
ENSG00000074527ENST00000547980F8W0I7
ENSG00000074527ENST00000553059Q9HB63

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Extracellular matrix organizationREACTOMER-HSA-1474244
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187191022008Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B.55
175455192007Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins.43
204070332010Netrin-4 induces lymphangiogenesis in vivo.29
190949842009Netrin-4 regulates angiogenic responses and tumor cell growth.21
198598012010Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.20
214061742011Netrin-4 delays colorectal cancer carcinomatosis by inhibiting tumor angiogenesis.20
224966212012Netrin-4 promotes glioblastoma cell proliferation through integrin β4 signaling.20
217991542011Netrin-4 activates endothelial integrin {alpha}6{beta}1.17
241205012013miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells.17
268635702016Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer.16

Citation

Dessen P

NTN4 (netrin 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47709/ntn4