NTRK1 (neurotrophic receptor tyrosine kinase 1)

2003-02-01  

Identity

HGNC
NTRK1
LOCATION
1q23.1
LOCUSID
4914
ALIAS
MTC,TRK,TRK1,TRKA,Trk-A,p140-TrkA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4914
MIM: 191315
HGNC: 8031
Ensembl: ENSG00000198400

Variants:

dbSNP: 4914
ClinVar: 4914
TCGA: ENSG00000198400
COSMIC: NTRK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198400ENST00000358660J3KP20
ENSG00000198400ENST00000368196P04629
ENSG00000198400ENST00000368196X5DR71
ENSG00000198400ENST00000392302P04629
ENSG00000198400ENST00000497019E9PQG0
ENSG00000198400ENST00000524377P04629

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
ApoptosisKEGGko04210
Thyroid cancerKEGGko05216
MAPK signaling pathwayKEGGhsa04010
ApoptosisKEGGhsa04210
Pathways in cancerKEGGhsa05200
Thyroid cancerKEGGhsa05216
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Activation of TRKA receptorsREACTOMER-HSA-187015
TRKA activation by NGFREACTOMER-HSA-187042
NGF-independant TRKA activationREACTOMER-HSA-187024
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
PLC-gamma1 signallingREACTOMER-HSA-167021
PI3K/AKT activationREACTOMER-HSA-198203
Signalling to STAT3REACTOMER-HSA-198745
Retrograde neurotrophin signallingREACTOMER-HSA-177504

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA154410481prasugrelChemicalClinicalAnnotationassociatedPD23859572, 28820077
PA166182733larotrectinib sulfateChemicalLabelAnnotationassociated
PA166190161entrectinibChemicalLabelAnnotationassociated
PA34335RETGeneDataAnnotationassociated
PA445857Thyroid NeoplasmsDiseaseLiterature, MultilinkAnnotationassociated23788249
PA446649Carcinoma, MedullaryDiseaseDataAnnotationassociated
PA448497aspirinChemicalClinicalAnnotationassociatedPD23859572, 28820077

References

Pubmed IDYearTitleCitations
241628152013Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.158
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
182703282008Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.90
194170272009Trk receptor expression and inhibition in neuroblastomas.88
171965282007Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.85
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
187278392008Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc.63
154887582004TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.62
265462952016Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.62

Citation

Dessen P

NTRK1 (neurotrophic receptor tyrosine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/216/ntrk1