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NTRK1 (neurotrophic tyrosine kinase, receptor, type 1)

Identity

Other namesDKFZp781I14186
MTC
TRK
TRK1
TRKA
p140-TrkA
HGNC (Hugo) NTRK1
Location 1q23.1
Location_base_pair Starts at 155052166 and ends at 155118266 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 

External links

Nomenclature
HGNC (Hugo)NTRK1   8031
Entrez_Gene (NCBI)NTRK1  4914  neurotrophic tyrosine kinase, receptor, type 1
Cards
GeneCards (Weizmann)NTRK1
Ensembl (Hinxton)ENSG00000198400 [Gene_View]  NTRK1 [Vega]
AceView (NCBI)NTRK1
Genatlas (Paris)NTRK1
euGene (Indiana)4914
SOURCE (Stanford)NM_001007792 NM_001012331 NM_002529
Gene Expression (Array Express) ENSG00000198400
Genomic and cartography
GoldenPath (UCSC)NTRK1  -  1q23.1   chr1:155052166-155118266 +  1q23.1   [Description]    (hg18-March_2006)
EnsemblNTRK1 - 1q23.1 [CytoView]
Mapping of homologs : NCBINTRK1 [Mapview]
OMIM155240   191315   256800   
Gene and transcription
Gene : Genbank (Entrez)AK126428 AK290759 AK312704 BC062580 BC136554
Reference sequence (RefSeq transcript) :SRSNM_001007792 NM_001012331 NM_002529
Reference transcript : EntrezNM_001007792 NM_001012331 NM_002529
RefSeq genomic : SRSAC_000044 AC_000133 NC_000001 NG_007493 NT_004487 NW_001838531 NW_925683
RefSeq genomic : EntrezAC_000044 AC_000133 NC_000001 NG_007493 NT_004487 NW_001838531 NW_925683
Consensus coding sequences : CCDS NCBINTRK1
Cluster EST : UnigeneHs.406293 [ SRS ] Hs.406293 [ NCBI ]
Alternative Splicing : Fast-db (Paris)17417
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP04629 (SRS) P04629 (Expasy) P04629 (Uniprot)
With graphics : InterProP04629
Splice isoforms : VarSplice FASTAP04629(VarSplice FASTA)
Domaine pattern : Prosite (SRS)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domain pattern : Prosite (Expaxy)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (SRS)Cys-rich_flank_reg_C    Ig-like    Ig-like_fold    Ig_sub    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Tyr_kinase_neurotrophic_rcpt_1    Tyr_kinase_neurotrophic_rcpt_N    Tyr_prot_kinase    Tyr_prot_kinase_AS    Tyr_prot_kinase_cat_dom    Tyr_prot_kinase_rcpt_2_CS    Tyr_prot_kinase_subgr_cat_dom   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Ig-like    Ig-like_fold    Ig_sub    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Tyr_kinase_neurotrophic_rcpt_1    Tyr_kinase_neurotrophic_rcpt_N    Tyr_prot_kinase    Tyr_prot_kinase_AS    Tyr_prot_kinase_cat_dom    Tyr_prot_kinase_rcpt_2_CS    Tyr_prot_kinase_subgr_cat_dom   
Related proteins : CluSTrP04629
Domain families : Pfam SRSPkinase_Tyr (PF07714)   
Domain families : Pfam SangerPkinase_Tyr (PF07714)   
Domain families : Pfam NCBIpfam07714   
Domain families : Smart EMBLIG (SM00409)  LRRCT (SM00082)  TyrKc (SM00219)  
Blocks (Seattle)P04629
Crystal structure of protein : PDB SRS1HE7    1SHC    1WWA    1WWW    2IFG   
Crystal structure of protein : PDBSum1HE7    1SHC    1WWA    1WWW    2IFG   
Crystal structure of protein : IMB1HE7    1SHC    1WWA    1WWW    2IFG   
Crystal structure of protein : PDB RSDB1HE7    1SHC    1WWA    1WWW    2IFG   
HPRD01869
Protein Interaction databases
DIP (DOE-UCLA)P04629
IntAct (EBI)P04629
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBINTRK1
SNP : GeneSNP UtahNTRK1
SNP : HGBaseNTRK1
Genetic variants : HAPMAPNTRK1
Cancer Gene: CensusNTRK1 
Somatic Mutations in Cancer : COSMICNTRK1 
Translocation Breakpoints in Cancer : TICdbnucleotide 
Mutations and Diseases : HGMDNTRK1
Hereditary diseases : OMIM155240    191315    256800   
Hereditary diseases : GENETests155240    191315    256800   
Diseases : Genetic AssociationNTRK1
General knowledge
Homologs : HomoloGeneNTRK1
Homology/Alignments : Family Browser UCSCNTRK1
Phylogenetic Trees/Animal Genes : TreeFamNTRK1
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Chemical/Protein Interactions : CTD4914
Keywords Ontology : AmiGOnucleotide binding  transmembrane receptor protein tyrosine kinase activity  neurotrophin receptor activity  protein binding  ATP binding  cytoplasm  endosome  plasma membrane  integral to plasma membrane  protein amino acid phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  activation of adenylate cyclase activity  Ras protein signal transduction  multicellular organismal development  nervous system development  transferase activity  cell differentiation  B cell differentiation  mechanoreceptor differentiation  negative regulation of neuron apoptosis  
Keywords Ontology : EGO-EBInucleotide binding  transmembrane receptor protein tyrosine kinase activity  neurotrophin receptor activity  protein binding  ATP binding  cytoplasm  endosome  plasma membrane  integral to plasma membrane  protein amino acid phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  activation of adenylate cyclase activity  Ras protein signal transduction  multicellular organismal development  nervous system development  transferase activity  cell differentiation  B cell differentiation  mechanoreceptor differentiation  negative regulation of neuron apoptosis  
Pathways : BIOCARTAY branching of actin filaments [Genes]    Role of Erk5 in Neuronal Survival [Genes]    Trka Receptor Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathwayApoptosis
Other databases
Probes
Probes : ImagenesNTRK1 Related clones (RZPD - Berlin)
Literature
PubMed176 Pubmed reference(s) in Entrez
PubGeneNTRK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:29:50 CET 2010
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