NUCB2 (nucleobindin 2)

2007-02-01  

Identity

HGNC
NUCB2
LOCATION
11p15.1
LOCUSID
4925
ALIAS
HEL-S-109,NEFA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4925
MIM: 608020
HGNC: 8044
Ensembl: ENSG00000070081

Variants:

dbSNP: 4925
ClinVar: 4925
TCGA: ENSG00000070081
COSMIC: NUCB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070081ENST00000323688P80303
ENSG00000070081ENST00000458064Q2L696
ENSG00000070081ENST00000526120E9PJP3
ENSG00000070081ENST00000527580H0YEG8
ENSG00000070081ENST00000527735H0YD18
ENSG00000070081ENST00000528644A0A1B0GXJ7
ENSG00000070081ENST00000529010P80303
ENSG00000070081ENST00000529313E9PLR0
ENSG00000070081ENST00000530527E9PLE9
ENSG00000070081ENST00000530964E9PLR5
ENSG00000070081ENST00000531172E9PRQ3
ENSG00000070081ENST00000533738E9PJP3
ENSG00000070081ENST00000533773E9PKG6
ENSG00000070081ENST00000533926E9PM22
ENSG00000070081ENST00000622082P80303
ENSG00000070081ENST00000646648A0A2R8Y6G7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseClinicalAnnotation, Literature, MultilinkAnnotationassociatedPD24560520, 31327267
PA449899hydrochlorothiazideChemicalClinicalAnnotationassociatedPD31327267

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
204274812010Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity.53
164072802006Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex.31
164072802006Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex.31
200322012010Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state.31
216536972011G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs.27
219885942012Nucleobindin 2 in human breast carcinoma as a potent prognostic factor.23
209373362011Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa.20
212522512011Decreased cerebrospinal fluid/plasma ratio of the novel satiety molecule, nesfatin-1/NUCB-2, in obese humans: evidence of nesfatin-1/NUCB-2 resistance and implications for obesity treatment.20
222259872012Nesfatin-1, a unique regulatory neuropeptide of the brain.20

Citation

Dessen P

NUCB2 (nucleobindin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46341/nucb2