NUDC (nuclear distribution C, dynein complex regulator)

2007-02-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
HNUDC,MNUDC,NPD011
FUSION GENES

Other Information

Locus ID:

NCBI: 10726
MIM: 610325
HGNC: 8045
Ensembl: ENSG00000090273

Variants:

dbSNP: 10726
ClinVar: 10726
TCGA: ENSG00000090273
COSMIC: NUDC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090273ENST00000321265Q9Y266
ENSG00000090273ENST00000435827A0A0A0MSU9
ENSG00000090273ENST00000452707A0A0A0MSS4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128528572003A role for Plk1 phosphorylation of NudC in cytokinesis.54
168607402006NudC is required for Plk1 targeting to the kinetochore and chromosome congression.40
126793842003Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis.39
206753722010The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.15
240692382013NudC deacetylation regulates mitotic progression.11
205298572010Identification of the residues in the extracellular domain of thrombopoietin receptor involved in the binding of thrombopoietin and a nuclear distribution protein (human NUDC).9
146768312004Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein.7
160889172005A microtubule associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl).6
182881302008hNUDC promotes the cell proliferation and differentiation in a leukemic cell line via activation of the thrombopoietin receptor (Mpl).6
195604572009Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation.5

Citation

Dessen P

NUDC (nuclear distribution C, dynein complex regulator)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46349/nudc