NUDT16L1 (nudix hydrolase 16 like 1)

2017-04-01  

Identity

HGNC
NUDT16L1
LOCATION
16p13.3
LOCUSID
84309
ALIAS
SDOS,TIRR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84309
MIM: 617338
HGNC: 28154
Ensembl: ENSG00000168101

Variants:

dbSNP: 84309
ClinVar: 84309
TCGA: ENSG00000168101
COSMIC: NUDT16L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168101ENST00000304301Q9BRJ7
ENSG00000168101ENST00000405142Q9BRJ7
ENSG00000168101ENST00000586252K7ENA3
ENSG00000168101ENST00000586536W4VSQ8
ENSG00000168101ENST00000590460K7EIN2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
282411362017TIRR regulates 53BP1 by masking its histone methyl-lysine binding function.33
282135172017The p53-binding protein 1-Tudor-interacting repair regulator complex participates in the DNA damage response.14
298444952018Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR.11
299675382018Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.7
300023772018Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR.6
302604312018Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation.1

Citation

Dessen P

NUDT16L1 (nudix hydrolase 16 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56734/nudt16l1