NUF2 (NUF2 component of NDC80 kinetochore complex)

2006-10-01  

Identity

HGNC
NUF2
LOCATION
1q23.3
LOCUSID
83540
ALIAS
CDCA1,CT106,NUF2R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83540
MIM: 611772
HGNC: 14621
Ensembl: ENSG00000143228

Variants:

dbSNP: 83540
ClinVar: 83540
TCGA: ENSG00000143228
COSMIC: NUF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143228ENST00000271452Q9BZD4
ENSG00000143228ENST00000367900Q9BZD4
ENSG00000143228ENST00000442820B1AQT4
ENSG00000143228ENST00000450453B1AQT3
ENSG00000143228ENST00000497990E9PP32
ENSG00000143228ENST00000524800E9PQC4
ENSG00000143228ENST00000534289E9PKH1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

References

Pubmed IDYearTitleCitations
124384182002hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells.110
155485922005Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites.105
159614012005Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.83
195259382009Chromosome congression in the absence of kinetochore fibres.73
212704392011The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosis.48
175358142007Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment.32
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
187708612008HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL.26
198786542009siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis.26
230565892012An RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer.24

Citation

Dessen P

NUF2 (NUF2 component of NDC80 kinetochore complex)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43200/nuf2