NUMBL (NUMB like endocytic adaptor protein)

2007-04-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
CAG3A,CTG3a,NBL,NUMB-R,NUMBLIKE,NUMBR,TNRC23
FUSION GENES

Other Information

Locus ID:

NCBI: 9253
MIM: 604018
HGNC: 8061
Ensembl: ENSG00000105245

Variants:

dbSNP: 9253
ClinVar: 9253
TCGA: ENSG00000105245
COSMIC: NUMBL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105245ENST00000252891Q9Y6R0
ENSG00000105245ENST00000540131A0A0C4DGH3
ENSG00000105245ENST00000595741M0QZV7
ENSG00000105245ENST00000598773M0QYC2
ENSG00000105245ENST00000598779A0A0C4DGH3
ENSG00000105245ENST00000600636M0R0Q4
ENSG00000105245ENST00000600967M0QXQ4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
234404232013Regulation of lung cancer metastasis by Klf4-Numb-like signaling.21
225932072012Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation.16
275212172016Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl.15
200797152010NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.14
280676682017Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.13
276138382016Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy.11
273831822016Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis.8
236818002013Numblike regulates proliferation, apoptosis, and invasion of lung cancer cell.6
168993522006Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects.4
189404732008Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors.4

Citation

Dessen P

NUMBL (NUMB like endocytic adaptor protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47456/numbl