NUP93 (nucleoporin 93)

2007-04-01 Affiliation

Identity

HGNC

NUP93

LOCATION

16q13

LOCUSID

9688

ALIAS

NIC96

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9688
MIM: 614351
HGNC: 28958
Ensembl: ENSG00000102900

Variants:

dbSNP: 9688
ClinVar: 9688
TCGA: ENSG00000102900
COSMIC: NUP93

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102900	ENST00000308159	Q8N1F7
ENSG00000102900	ENST00000542526	Q8N1F7
ENSG00000102900	ENST00000562496	H3BV11
ENSG00000102900	ENST00000563405	H3BVE2
ENSG00000102900	ENST00000563486	H3BRD9
ENSG00000102900	ENST00000563858	H3BPA9
ENSG00000102900	ENST00000564887	Q8N1F7
ENSG00000102900	ENST00000566315	H3BRI8
ENSG00000102900	ENST00000566678	H3BNN5
ENSG00000102900	ENST00000567081	H3BP72
ENSG00000102900	ENST00000567641	H3BP95
ENSG00000102900	ENST00000568283	H3BNG7
ENSG00000102900	ENST00000568656	H3BM93
ENSG00000102900	ENST00000569322	H3BV15
ENSG00000102900	ENST00000569842	H3BVG0
ENSG00000102900	ENST00000569863	H3BMX0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
Nuclear pore complex	KEGG	hsa_M00427
Nuclear pore complex	KEGG	M00427
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
SUMOylation	REACTOME	R-HSA-2990846
SUMO E3 ligases SUMOylate target proteins	REACTOME	R-HSA-3108232
SUMOylation of DNA damage response and repair proteins	REACTOME	R-HSA-3108214
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Rev-mediated nuclear export of HIV RNA	REACTOME	R-HSA-165054
Host Interactions of HIV factors	REACTOME	R-HSA-162909
Interactions of Vpr with host cellular proteins	REACTOME	R-HSA-176033
Vpr-mediated nuclear import of PICs	REACTOME	R-HSA-180910
Interactions of Rev with host cellular proteins	REACTOME	R-HSA-177243
Nuclear import of Rev protein	REACTOME	R-HSA-180746
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Transport of Ribonucleoproteins into the Host Nucleus	REACTOME	R-HSA-168271
Influenza Viral RNA Transcription and Replication	REACTOME	R-HSA-168273
Viral Messenger RNA Synthesis	REACTOME	R-HSA-168325
Export of Viral Ribonucleoproteins from Nucleus	REACTOME	R-HSA-168274
NEP/NS2 Interacts with the Cellular Export Machinery	REACTOME	R-HSA-168333
Host Interactions with Influenza Factors	REACTOME	R-HSA-168253
NS1 Mediated Effects on Host Pathways	REACTOME	R-HSA-168276
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
Transport of Mature Transcript to Cytoplasm	REACTOME	R-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing Transcript	REACTOME	R-HSA-159236
Transport of Mature mRNAs Derived from Intronless Transcripts	REACTOME	R-HSA-159234
Transport of the SLBP Dependant Mature mRNA	REACTOME	R-HSA-159230
Transport of the SLBP independent Mature mRNA	REACTOME	R-HSA-159227
Transport of Mature mRNA Derived from an Intronless Transcript	REACTOME	R-HSA-159231
Gene Silencing by RNA	REACTOME	R-HSA-211000
Transcriptional regulation by small RNAs	REACTOME	R-HSA-5578749
Metabolism of non-coding RNA	REACTOME	R-HSA-194441
snRNP Assembly	REACTOME	R-HSA-191859
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Nuclear Envelope Breakdown	REACTOME	R-HSA-2980766
Nuclear Pore Complex (NPC) Disassembly	REACTOME	R-HSA-3301854
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Hexose transport	REACTOME	R-HSA-189200
Glucose transport	REACTOME	R-HSA-70153
Regulation of Glucokinase by Glucokinase Regulatory Protein	REACTOME	R-HSA-170822
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
Regulation of HSF1-mediated heat shock response	REACTOME	R-HSA-3371453
tRNA processing	REACTOME	R-HSA-72306
tRNA processing in the nucleus	REACTOME	R-HSA-6784531
SUMOylation of RNA binding proteins	REACTOME	R-HSA-4570464
SUMOylation of DNA replication proteins	REACTOME	R-HSA-4615885

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
26878725	2016	Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome.	38
27593162	2016	Congenital Heart Disease Genetics Uncovers Context-Dependent Organization and Function of Nucleoporins at Cilia.	32
16286466	2006	Caspases target only two architectural components within the core structure of the nuclear pore complex.	13
29869118	2018	Genetic diagnosis of steroid-resistant nephrotic syndrome in a longitudinal collection of Czech and Slovak patients: a high proportion of causative variants in NUP93.	2
30741391	2019	Biallelic Variants in the Nuclear Pore Complex Protein NUP93 Are Associated with Non-progressive Congenital Ataxia.	2
30943371	2019	SARS coronavirus protein nsp1 disrupts localization of Nup93 from the nuclear pore complex.	1
31774908	2019	Expression of Nup93 is associated with the proliferation, migration and invasion capacity of cervical cancer cells.	0

Citation

Dessen P

NUP93 (nucleoporin 93)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47170/nup93